Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy
Gilead Study Director Study Director Gilead Sciences
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University Hospital rechts der Isar Technical University of Munich 81675 Bayern (Bayern) GermanyRekrutierend» Google-MapsVivantes Klinikum am Urban 10967 Berlin (Berlin) GermanyRekrutierend» Google-MapsHELIOS Klinikum Berlin-Buch 13125 Berlin (Berlin) GermanyRekrutierend» Google-Maps
Brustzentrum Marienhospital Bottrop Josef-Albers-Straße 70 46236 Bottrop DeutschlandRekrutierend» Google-MapsUniversitätsklinik Erlangen 91054 Erlangen (Bayern) GermanyRekrutierend» Google-MapsSRH Wald-Klinikum Gera GmbH 07548 Gera (Thüringen) GermanyRekrutierend» Google-MapsUniversitatsklinikum Hamburg-Eppendorf 20246 Hamburg (Hamburg) GermanyRekrutierend» Google-MapsLeberkrebszentrum Medizinische Hochschule Hannover Carl-Neuberg-Straße 1 30625 Hannover DeutschlandRekrutierend» Google-MapsNationales Centrum für Tumorerkrankungen Heidelberg 69120 Heidelberg (Baden-Württemberg) GermanyRekrutierend» Google-MapsDarmkrebszentrum Universitätsklinikum Mannheim Theodor-Kutzer-Ufer 1 - 3 68167 Mannheim DeutschlandRekrutierend» Google-MapsUniversitatsklinikum Munster 48149 Munster (Nordrhein-Westfalen) GermanyRekrutierend» Google-MapsLMU Klinikum der Universitat München 81377 München (Bayern) GermanyRekrutierend» Google-MapsUniversitäts - Frauenklinik 72076 Tübingen (Baden-Württemberg) GermanyRekrutierend» Google-MapsIronwood Physicians P.C. dba Ironwood Cancer and Research Centers 85224 Chandler United StatesRekrutierend» Google-MapsLos Angeles Hematology Oncology Medical Group 90017 Los Angeles United StatesRekrutierend» Google-MapsStanford Cancer Institute 94305 Palo Alto United StatesRekrutierend» Google-MapsUniversity of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center 94143 San Francisco United StatesRekrutierend» Google-MapsRocky Mountain Cancer Centers, LLP 80120 Littleton United StatesRekrutierend» Google-MapsYale-New Haven Hospital-Yale Cancer Center 06510 New Haven United StatesRekrutierend» Google-MapsInvestigational Drug Services, AdventHealth Orlando 32701 Altamonte Springs United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 34613 Brooksville United StatesRekrutierend» Google-MapsFlorida Cancer Specialist 34748 Leesburg United StatesRekrutierend» Google-MapsFlorida Cancer Specialist 33705 Saint Petersburg United StatesRekrutierend» Google-MapsPiedmont Cancer Institute 30318 Atlanta United StatesRekrutierend» Google-MapsGeorgia Cancer Specialist - Annex 30341 Atlanta United StatesRekrutierend» Google-MapsNorthwest Georgia Oncology Centers 30060 Marietta United StatesRekrutierend» Google-MapsThe University of Kansas Hospital 66160 Kansas City United StatesRekrutierend» Google-MapsHematology Oncology Clinic 70809 Baton Rouge United StatesRekrutierend» Google-MapsSaint Luke's Cancer Institute 64110 Kansas City United StatesRekrutierend» Google-MapsDavid C. Pratt Cancer Center 63141 Saint Louis United StatesRekrutierend» Google-MapsAstera Cancer Care 08816 East Brunswick United StatesRekrutierend» Google-MapsRutgers Cancer Institute of New Jersey 08901 New Brunswick United StatesRekrutierend» Google-MapsMemorial Sloan-Kettering Cancer Center (MSKCC) - New York 10065 New York United StatesRekrutierend» Google-MapsCleveland Clinic 44195 Cleveland United StatesRekrutierend» Google-MapsPenn State Cancer Institute 17033 Hershey United StatesRekrutierend» Google-MapsMagee-Womens of UPMC 15213 Pittsburgh United StatesRekrutierend» Google-MapsPrisma Health - Upstate 29605 Greenville United StatesRekrutierend» Google-MapsTennessee Oncology, PLLC 37203 Nashville United StatesRekrutierend» Google-MapsVanderbilt University Medical Center - Vanderbilt-Ingram Cancer Center 37203 Nashville United StatesRekrutierend» Google-MapsUS Oncology Investigational Products Center (IPC) 22031 Fairfax United StatesRekrutierend» Google-MapsUS Oncology Investigational Products Center (IPC) 23502 Norfolk United StatesRekrutierend» Google-MapsMultiCare Regional Cancer Center - Auburn 98001 Auburn United StatesRekrutierend» Google-MapsHospital Britanico de Buenos Aires 1426 Buenos Aires ArgentinaRekrutierend» Google-MapsInstituto de Investigaciones Clinicas de Mar del Plata B7600 Buenos Aires ArgentinaRekrutierend» Google-MapsInstituto Alexander Fleming 1426ANZ C.a.b.a. ArgentinaRekrutierend» Google-MapsHospital Alemán 1118 Caba ArgentinaRekrutierend» Google-MapsCentro Privado de RMI Rio Cuarto S.A. 5800 Cordoba ArgentinaRekrutierend» Google-MapsInstituto de Oncología de Rosario 2000 Rosario ArgentinaRekrutierend» Google-MapsCER San Juan Centro Polivalente de Asistencia e Investigación Clínica 5400 San Juan ArgentinaRekrutierend» Google-MapsRoyal Brisbane and Women's Hospital 4029 Queensland AustraliaRekrutierend» Google-MapsSt Vincent's Hospital Sydney 2010 Darlinghurst AustraliaRekrutierend» Google-MapsLiverpool Hospital 2170 Liverpool AustraliaRekrutierend» Google-MapsGenesisCare North Shore (Oncology) 2065 St Leonards AustraliaRekrutierend» Google-MapsIcon Cancer Centre Wesley 4066 Auchenflower AustraliaRekrutierend» Google-MapsFlinders Medical Centre 5042 Bedford Park AustraliaRekrutierend» Google-MapsIcon Cancer Centre Hobart 7000 Hobart AustraliaRekrutierend» Google-MapsAustin Health 3084 Melbourne AustraliaRekrutierend» Google-MapsSunshine Hospital (Western Health) 3021 St Albans AustraliaRekrutierend» Google-MapsBreast Cancer Research Centre - WA 6009 Nedlands AustraliaRekrutierend» Google-MapsUniversity Hospital Innsbruck 06020 Innsbruck AustriaRekrutierend» Google-MapsUniversitätsklinik für Innere Medizin 3 der PMU A-5020 Salzburg AustriaRekrutierend» Google-MapsKlinikum Wels-Grieskirchen 4710 Wels AustriaRekrutierend» Google-MapsMedizinische Universitat Wien, Univ. Klinik fur Innere Medizin I Klinische Abteilung fur Onkologie 1090 Wien AustriaRekrutierend» Google-MapsGZA Ziekenhuizen - Campus Sint-Augustinus 2610 Antwerpen BelgiumRekrutierend» Google-MapsAZ Klina 2930 Brasschaat BelgiumRekrutierend» Google-MapsCliniques Universitaires Saint-Luc 1200 Brussels BelgiumRekrutierend» Google-MapsUniversitaire Ziekenhuis Leuven 3000 Leuven BelgiumRekrutierend» Google-MapsCHU UCL Namur-Site STE. Elisabeth 5000 Namur BelgiumRekrutierend» Google-MapsHospital Haroldo Juaçaba - Instituto do Câncer do Ceará 60430-230 Fortaleza BrazilRekrutierend» Google-MapsHospital Araujo Jorge - Associacao de Combate ao Cancer em Goias 74605-070 Goiânia BrazilRekrutierend» Google-MapsOncosite - Centro de Pesquisa Clinica e Oncologia 98700-000 Ijui BrazilRekrutierend» Google-MapsCatarina Pesquisa Clinica 88301-220 Itajai BrazilRekrutierend» Google-MapsOncoclinicas do Brasil Servicos Medicos AS 30360-680 Minas Gerais BrazilRekrutierend» Google-MapsLiga Norte-Rio-Grandense Contra o Câncer 59062-000 Natal BrazilRekrutierend» Google-MapsCIONC-Centro Integrado de Oncologia de Curitiba 80810050 Paraana BrazilRekrutierend» Google-MapsHospital Erasto Gaertner 81.520-060 Paraná BrazilRekrutierend» Google-MapsIMIP - Instituto de Medicina Integral Professor Fernando Figueira 50070550 Pernambuco BrazilRekrutierend» Google-MapsIrmandade da Santa Casa de Misericórdia de Porto Alegre 90020-090 Porto Alegre BrazilRekrutierend» Google-MapsHospital de Clínicas de Porto Alegre - HCPA 90035-903 Porto Alegre BrazilRekrutierend» Google-MapsHGB - Hospital Giovanni Battista/Mãe de Deus Center 90110-270 Porto Alegre BrazilRekrutierend» Google-MapsHospital São Lucas da PUCRS 90610001 Porto Alegre BrazilRekrutierend» Google-MapsInstituto Americas 22775-001 Rio de Janeiro BrazilRekrutierend» Google-MapsClínica de Oncologia de Porto Alegre Ltda - CLINIONCO 90430-090 Rio Grande Do Sul BrazilRekrutierend» Google-MapsUnidade de PesquisasClinicas em Oncologia - UPCO 96020-080 Rio Grande Do Sul BrazilRekrutierend» Google-MapsInstituto do Câncer - Hospital São Vicente de Paulo 99010-090 Rio Grande Do Sul BrazilRekrutierend» Google-MapsCEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia 09060-650 Santo Andre BrazilRekrutierend» Google-MapsInstituto Hemomed Oncologia e Hematologia 01236-030 São Paulo BrazilRekrutierend» Google-MapsClinica de pesquisa e centro de estudos em oncologia ginecológica e mamaria 1317000 São Paulo BrazilRekrutierend» Google-MapsBC Cancer - Kelowna V1Y 5L3 Kelowna CanadaRekrutierend» Google-MapsThe Ottawa Hospital Cancer Centre K1H 8L6 Ottawa CanadaRekrutierend» Google-MapsCHU de Québec-Université Laval, Hôpital du Saint-Sacrement G1S 4L8 Quebec CanadaRekrutierend» Google-MapsHumber River Hospital M3M 0B2 Toronto CanadaRekrutierend» Google-MapsBC Cancer-Victoria V8R 6V5 Victoria CanadaRekrutierend» Google-MapsCentro de Investigacion Clinica Bradford Hill Recoleta ChileRekrutierend» Google-MapsCentro del Cancer UC 7550000 Region Metropolitana ChileRekrutierend» Google-MapsCentro de Oncología de Precisión (COP) 8330032 Santiago Region ChileRekrutierend» Google-MapsJames Lind Centro de Investigacion del Cancer Temuco ChileRekrutierend» Google-MapsOncocentro APYS 2520612 Vina del Mar ChileRekrutierend» Google-MapsThe First Affiliated Hospital of USTC (Anhui Provincial Hospital) 230001 Anhui ChinaRekrutierend» Google-MapsPeking University People's Hospital 100044 Beijing ChinaRekrutierend» Google-MapsThe First Hospital of Jilin University 130021 Changchun ChinaRekrutierend» Google-MapsXiangya Hospital Central South University 410008 Changsha ChinaRekrutierend» Google-MapsWest China Hospital Sichuan University 610041 Chengdu ChinaRekrutierend» Google-MapsChongqing University Cancer Hospital 404100 Chongqing ChinaRekrutierend» Google-MapsFujian Cancer Hospital 350015 Fujian ChinaRekrutierend» Google-MapsFujian Medical University Union Hospital 350001 Fuzhou ChinaRekrutierend» Google-MapsSun Yat-Sen University Cancer Center 510060 Guangdong ChinaRekrutierend» Google-MapsGuangdong Provincial People's Hospital 510080 Guangzhou ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Sun Yat-sen University 510080 Guangzhou ChinaRekrutierend» Google-MapsSun Yat-Sen Memorial Hospital, Sun Yat-Sen University 510120 Guangzhou ChinaRekrutierend» Google-MapsSir Run Run Shaw Hospital,Zhejiang University School of Medicine 310000 Hangzhou ChinaRekrutierend» Google-MapsZhejiang Cancer Hospital 310022 Hangzhou ChinaRekrutierend» Google-MapsHarbin Medical University Cancer Hospital 150081 Heilongjiang ChinaRekrutierend» Google-MapsJiangsu Province Hospital 210029 Jiangsu ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Soochow University 215004 Jiangsu ChinaRekrutierend» Google-MapsThe Nanchang Third Hospital 330009 Jiangxi ChinaRekrutierend» Google-MapsThe Second Hospital of Jilin University 130041 Jilin Sheng ChinaRekrutierend» Google-MapsAffiliated Cancer Hospital of Shandong First Medical University 250117 Jinan ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Nanchang University 330006 Nanchang ChinaRekrutierend» Google-MapsGeneral Hospital of Ningxia Medical University 750004 Ningxia Hui ChinaRekrutierend» Google-MapsThe Affiliated Hospital Of Qingdao University 266071 Qingdao ChinaRekrutierend» Google-MapsFudan University Shanghai Cancer Center 200030 Shanghai ChinaRekrutierend» Google-MapsTianjin Medical University Cancer Institute & Hospital 453000 Tianjin ChinaRekrutierend» Google-MapsHubei Cancer Hospital 430079 Wuhan ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Xi'an Jiaotong University 710061 Xi'an ChinaRekrutierend» Google-MapsThe Second Affiliated Hospital of Zhejiang University School of Medicine 310009 Zhejiang ChinaRekrutierend» Google-MapsHenan Cancer Hospital 450003 Zhengzhou ChinaRekrutierend» Google-MapsFakultni Nemocnice Brno 62500 Brno CzechiaRekrutierend» Google-MapsMasaryk Memorial Cancer Institute 656 53 Brno CzechiaRekrutierend» Google-MapsUniversity Hospital Olomouc 779 00 Olomouc CzechiaRekrutierend» Google-MapsMultiscan s.r.o 532 01 Pardubice CzechiaRekrutierend» Google-MapsFakultni nemocnice v Motole 14059 Prague 4 CzechiaRekrutierend» Google-MapsCharles General University Hospital, Prague 12808 Prague CzechiaRekrutierend» Google-MapsKrajska nemocnice Tomase Bati Zlin 760 01 Zlin CzechiaRekrutierend» Google-MapsCHU Jean Minjoz 25030 Besancon FranceRekrutierend» Google-MapsInstitut Bergonié 33076 Bordeaux FranceRekrutierend» Google-MapsCentre Georges François Leclerc 21000 Dijon FranceRekrutierend» Google-MapsCentre Oscar Lambret 59000 Lille FranceRekrutierend» Google-MapsIco René Gauducheau 44 805 Loire Atlantique FranceRekrutierend» Google-MapsCentre Leon Berard 69373 Lyon FranceRekrutierend» Google-MapsInstitut Paoli Calmettes 13009 Marseille FranceRekrutierend» Google-MapsInstitut Regional du Cancer de Montpellier 34298 Montpellier Cedex 5 FranceRekrutierend» Google-MapsInstitut Curie 75248 Paris FranceRekrutierend» Google-MapsCentre Hospitalier Lyon-Sud 69310 Pierre-benite FranceRekrutierend» Google-MapsHopital Privé des Cotes d'Armor 22190 Plerin FranceRekrutierend» Google-MapsCentre Jean Bernard Service d'Oncologie Médicale 35042 Rennes Cedex FranceRekrutierend» Google-MapsCentre Henri Becquerel Rouen FranceRekrutierend» Google-MapsInstitut Universitaire du Cancer de Toulouse Oncopole 31059 Toulouse Cedex 9 FranceRekrutierend» Google-MapsInstitut Gustave Roussy 94800 Villejuif FranceRekrutierend» Google-MapsAlexandra General Hospital 11528 Athens GreeceRekrutierend» Google-MapsAttikon Hospital 124 62 Athens GreeceRekrutierend» Google-MapsUniversity Hospital of Heraklion Heraklion GreeceRekrutierend» Google-MapsUniversity Hospital of Larissa 41110 Larissa GreeceRekrutierend» Google-MapsUniversity Hospital of Patras 26 500 Patras GreeceRekrutierend» Google-MapsBioclinic of Thessaloniki 546 22 Thessaloniki GreeceRekrutierend» Google-MapsEuromedica General Clinic of Thessaloniki 546 45 Thessaloniki GreeceRekrutierend» Google-MapsHong Kong Integrated Oncology Centre Hong Kong Hong KongRekrutierend» Google-MapsPrince of Wales Hospital New Territories Hong KongRekrutierend» Google-MapsQueen Mary Hospital Pok Fu Lam Hong KongRekrutierend» Google-MapsSemmelweis Egyetem, Belgyogyaszati es Onkologiai Klinika 1083 Budapest HungaryRekrutierend» Google-MapsDebreceni Egyetem Klinikai Központ 4032 Debrecen HungaryRekrutierend» Google-MapsBács-Kiskun Varmegyei Oktatokorhaz, Onkaradiologiai Kozpont 6000 Kecskemét HungaryRekrutierend» Google-MapsSzabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz, Onkoradiologia 4400 Nyiregyhaza HungaryRekrutierend» Google-MapsSzegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont 6720 Szeged HungaryRekrutierend» Google-MapsOncology Institute Rambam Health Care Campus 31096 Haifa IsraelRekrutierend» Google-MapsShaare Zedek Medical Center 9103102 Jerusalem IsraelRekrutierend» Google-MapsHadassah Medical Center Jerusalem IsraelRekrutierend» Google-MapsRabin Medical Center 4941492 Petah Tikva IsraelRekrutierend» Google-MapsSheba Medical Center 52621 Ramat Gan IsraelRekrutierend» Google-MapsTel Aviv Sourasky Medical Center 64239 Tel Aviv IsraelRekrutierend» Google-MapsAzienda Ospedaliero Universitaria Ospedali Riuniti di Ancona 60126 Ancona AN ItalyRekrutierend» Google-MapsCentro di Riferimento Oncologico - IRCCS 33081 Aviano ItalyRekrutierend» Google-MapsHumanitas Gavazzeni 24125 Bergamo ItalyRekrutierend» Google-MapsASST Papa Giovanni XXIII 24127 Bergamo ItalyRekrutierend» Google-MapsIRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico di Sant'Orsola Bologna ItalyRekrutierend» Google-MapsHumanitas Istituto Clinico Catanese 95045 Catania ItalyRekrutierend» Google-MapsAzienda Ospedaliera Mater Domini 88100 Catanzaro ItalyRekrutierend» Google-MapsIRCCS Ospedale Policlinico San Martino 16132 Genova GE ItalyRekrutierend» Google-MapsFondazione IRCCS San Raffaele del Monte Tabor 20132 Milano ItalyRekrutierend» Google-MapsIstituto Europeo di Oncologia 20141 Milan ItalyRekrutierend» Google-MapsAzienda Ospedaliera San Gerardo 20090 Monza ItalyRekrutierend» Google-MapsIstituto Nazionale Tumori IRCCS Fondazione G. Pascale 80131 Napoli ItalyRekrutierend» Google-MapsIstituto Oncologico Veneto IOV 35128 Padova ItalyRekrutierend» Google-MapsIrccs Crob 85028 Rionero in Vulture ItalyRekrutierend» Google-MapsAzienda Ospedaliero-Universitaria Policlinico Umberto I 161 Roma ItalyRekrutierend» Google-MapsFondazione Policlinico Universitario Agostino Gemelli IRCCS 168 Roma ItalyRekrutierend» Google-MapsIstituto Clinico Humanitas 20089 Rozzano ItalyRekrutierend» Google-MapsAichi Cancer Center Hospital 464-8681 Aichi JapanRekrutierend» Google-MapsTohoku University Hospital 980-8574 Aoba-ku JapanRekrutierend» Google-MapsJuntendo University Hospital 113-8431 Bunkyo-ku JapanRekrutierend» Google-MapsChiba Cancer Center 260-8717 Chiba JapanRekrutierend» Google-MapsNational Cancer Center Hospital 1040045 Chuo-ku JapanRekrutierend» Google-MapsOsaka Prefectural Hospital Organization Osaka International Cancer Institute 541-8567 Chuo-ku JapanRekrutierend» Google-MapsNational Hospital Organization Shikoku Cancer Center 791-0280 Ehime JapanRekrutierend» Google-MapsFukushima Medical University Hospital Fukushima JapanRekrutierend» Google-MapsSocial Medical Corporation Hakuaikai Sagara Hospital 892-0833 Kagoshima-shi JapanRekrutierend» Google-MapsTokai University Hospital 259-1193 Kanagawa JapanRekrutierend» Google-MapsNational Cancer Center Hospital East 277-8577 Kashiwa JapanRekrutierend» Google-MapsSaitama Cancer Center 362-0806 Kitaadachi-gun JapanRekrutierend» Google-MapsCancer Institute Hospital of JFCR 135-8550 Koto-Ku JapanRekrutierend» Google-MapsKumamoto University Hospital 860-8556 Kumamoto- shi JapanRekrutierend» Google-MapsKyoto University Hospital 606-8507 Kyoto-shi JapanRekrutierend» Google-MapsNational Hospital Organization Kyushu Cancer Center 811-1395 Minami-ku JapanRekrutierend» Google-MapsNagoya University Hospital 466-8560 Nagoya JapanRekrutierend» Google-MapsHiroshima City Hiroshima Citizens Hospital 730-8518 Naka-ku JapanRekrutierend» Google-MapsHyogo Medical University Hospital 663-8501 Nishinomiya-shi JapanRekrutierend» Google-MapsOkayama University Hospital 700-8558 Okayama JapanRekrutierend» Google-MapsGunma Prefectural Cancer Center 373-8550 Ota JapanRekrutierend» Google-MapsNational Hospital Organization Hokkaido Cancer Center 003-0804 Sapporo JapanRekrutierend» Google-MapsCenter Hospital of the National Center for Global Health and Medicine 162-8655 Shinjuku-ku JapanRekrutierend» Google-MapsShowa University Hospital 142-8555 Tokyo JapanRekrutierend» Google-MapsKanagawa Cancer Center 241-8515 Yokohama JapanRekrutierend» Google-MapsSamsung Medical Center 06351 Gangnam-Gu Korea, Republic ofRekrutierend» Google-MapsNational Cancer Center 10408 Goyang-si Gyeonggi-do Korea, Republic ofRekrutierend» Google-MapsKyungpook National University Chilgok Hospital 41404 Gyeongsangbuk-do Korea, Republic ofRekrutierend» Google-MapsGachon University Gil Medical Center 21565 Incheon Korea, Republic ofRekrutierend» Google-MapsSeoul National University Bundang Hospital 13620 Seongnam Korea, Republic ofRekrutierend» Google-MapsKorea University Anam Hospital 02841 Seoul Korea, Republic ofRekrutierend» Google-MapsSeoul National University Hospital 03080 Seoul Korea, Republic ofRekrutierend» Google-MapsSeverance Hospital, Yonsei University Health System 03722 Seoul Korea, Republic ofRekrutierend» Google-MapsAsan Medical Center 05505 Seoul Korea, Republic ofRekrutierend» Google-MapsHospital Kuala Lumpur 50586 Kuala Lumpur MalaysiaRekrutierend» Google-MapsUniversity Malaya Medical Centre 59100 Kuala Lumpur MalaysiaRekrutierend» Google-MapsSarawak General Hospital 93586 Kuching MalaysiaRekrutierend» Google-MapsInstitut Kanser Negara 62250 Putrajaya MalaysiaRekrutierend» Google-MapsCentro de Investigacion y Avances Medicos Especializados 77550 Cancún MexicoRekrutierend» Google-MapsCOI Centro Oncologico Internacional S.A.P.I. de C.V. 04700 Mexico City MexicoRekrutierend» Google-MapsFUCAM 4980 México MexicoRekrutierend» Google-MapsClinica Integral Internacional de Oncologia S de RL de CV 72530 Puebla MexicoRekrutierend» Google-MapsCentro Medico Zambrano Hellion 64710 San Pedro Garza García MexicoRekrutierend» Google-MapsCentro de Atención e Investigación Clínica en Oncología 97134 Yucatán MexicoRekrutierend» Google-MapsCopemicus Podmiot Leczniczy Wojewodzkie Centrum Okologii w Gdansku 80-219 Gdansk PolandRekrutierend» Google-MapsSzpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z.o.o 31-826 Krakow PolandRekrutierend» Google-MapsInstytut MSF Sp. z o.o. 90-302 Lodz PolandRekrutierend» Google-MapsWojewodzki Szpital Specjalistyczny lm. Stefana Kardynala Wyszynsklego SPZOZ w Lublinie 19713 Lublin PolandRekrutierend» Google-MapsLUX MED Onkologia Sp. Zo.o. 01-748 Warszawa PolandRekrutierend» Google-MapsMaria Sklodowska - Curie Institute of Oncology 02-781 Warszawa PolandRekrutierend» Google-MapsCentro Clinico Academico - Hospital de Braga Braga PortugalRekrutierend» Google-MapsHospital da Senhora da Oliveira Guimaraes 4835-044 Guimarães PortugalRekrutierend» Google-MapsCentro Hospitalar de Lisboa Central, E.P.E . - Hospital de Santo Antonio dos Capuchos 1153-302 Lisbon PortugalRekrutierend» Google-MapsFundacao Champalimaud 1400-038 Lisbon PortugalRekrutierend» Google-MapsCentro Hospitalar Lisboa Norte, EPE 1649-035 Lisbon PortugalRekrutierend» Google-MapsUnidade Local de Saude de Matosinhos EPE - Hospital Pedro Hispano 4464-513 Matosinhos PortugalRekrutierend» Google-MapsNational University Hospital 119228 Singapore SingaporeRekrutierend» Google-MapsNational Cancer Centre Singapore 169610 Singapore SingaporeRekrutierend» Google-MapsTan Tock Seng Hospital 308433 Singapore SingaporeRekrutierend» Google-MapsWilgers Oncology Centre 0081 Gauteng South AfricaRekrutierend» Google-MapsThe Medical Oncology Centre of Rosebank 2196 Johannesburg South AfricaRekrutierend» Google-MapsCape Town Oncology Trials 7570 Kraaifontein South AfricaRekrutierend» Google-MapsHospital Universitari Dexeus 08028 Barcelona SpainRekrutierend» Google-MapsHospital Clinic de Barcelona 08036 Barcelona SpainRekrutierend» Google-MapsHospital Universitari Vall D'Hebron 8035 Barcelona SpainRekrutierend» Google-MapsHospital de Basurto 48013 Bilbo SpainRekrutierend» Google-MapsHospital Universitario Reina Sofia 14004 Córdoba SpainRekrutierend» Google-MapsHospital General Universitario De Elche 3203 Elche SpainRekrutierend» Google-MapsHospital Universitario de Jaen 23007 Jaen SpainRekrutierend» Google-MapsHospital General Universitario Gregorio Marañón 28007 Madrid SpainRekrutierend» Google-MapsMD Anderson Cancer Center 28033 Madrid SpainRekrutierend» Google-MapsHospital Universitario Ramón y Cajal 28034 Madrid SpainRekrutierend» Google-MapsHospital Clinico San Carlos 28040 Madrid SpainRekrutierend» Google-MapsHospital Universitario 12 de Octubre 28041 Madrid SpainRekrutierend» Google-MapsHospital Universitario de Salamanca 37002 Salamanca SpainRekrutierend» Google-MapsHospital Clínico Universitario de Santiago de Compostela - CHUS 15706 Santiago de Compostela SpainRekrutierend» Google-MapsHospital Universitario Virgen Macarena 41071 Sevilla SpainRekrutierend» Google-MapsHospital Universitario Virgen del Rocio 41013 Seville SpainRekrutierend» Google-MapsInstituto Valenciano De Oncologia (IVO) 46009 Valencia SpainRekrutierend» Google-MapsHospital Clínico Universitario de Valencia 46010 Valencia SpainRekrutierend» Google-MapsKaohsiung Chang Gung Memorial Hospital 83301 Kaohsiung City TaiwanRekrutierend» Google-MapsKaohsiung Medical University Chung-Ho Memorial Hospital 807 Kaohsiung TaiwanRekrutierend» Google-MapsTaipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare 235 New Taipei City TaiwanRekrutierend» Google-MapsChi Mei Hospital, Liouying 73657 Tainan City TaiwanRekrutierend» Google-MapsNational Cheng Kung University Hospital 704 Tainan TaiwanRekrutierend» Google-MapsTaipei Veterans General Hospital 11217 Taipei City TaiwanRekrutierend» Google-MapsNational Taiwan University Hospital 10048 Taipei TaiwanRekrutierend» Google-MapsTri-Service General Hospital 11490 Taipei TaiwanRekrutierend» Google-MapsKoo Foundation Sun Yat-Sen Cancer Center 999999 Taipei TaiwanRekrutierend» Google-MapsChang Gung Memorial Hospital, Linkou 33305 Taoyuan City TaiwanRekrutierend» Google-MapsBarts Cancer Institute EC1A 7BE London United KingdomRekrutierend» Google-MapsUniversity College London Hospitals NW1 2PG London United KingdomRekrutierend» Google-MapsThe Royal Marsden NHS Foundation Trust SW10 9NH London United KingdomRekrutierend» Google-MapsThe Christie NHS Foundation Trust M20 4BX Manchester United KingdomRekrutierend» Google-MapsNottingham University Hospitals NHS Trust NG5 1PB Nottingham United KingdomRekrutierend» Google-Maps
1. Progression Free Survival (PFS) as Assessed by Blinded Independent Central Review (BICR) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1) (Time Frame - Up to approximately 29 months): PFS is defined as time from date of randomization until the date of first objective progressive disease (PD) or death from any cause, whichever comes first.
Secondary outcome:
1. Overall Survival (OS) (Time Frame - Until death, up to approximately 60 months): OS is defined as the time from randomization until the date of death from any cause.
2. Objective Response Rate (ORR) as Assessed by BICR per RECIST Version 1.1 (Time Frame - Until progression, up to approximately 60 months): ORR is defined as the proportion of participants who achieve a complete response (CR) or partial response (PR) that is confirmed at least 4 weeks after initial documentation of response.
3. Change from Baseline in the Physical Functioning Domain Using European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Version 3.0 (EORTC QLQ-C30) at Week 16 (Time Frame - Baseline, Week 16): The EORTC QLQ-C30 is composed of global health status/QoL scale; five functional domains (physical, role, emotional, cognitive, and social); three symptom domains (fatigue, nausea and vomiting, and pain); and six single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties).
The Physical Functioning domain includes 5 questions in which participants will be asked to rate their overall health and overall quality of life as it relates to physical functioning during the past week on a scale from 1 (very poor) to 4 (excellent), with a higher score representing a high QoL.
4. Time to Deterioration in Version 3.0 EORTC-QLQ-C30 Scores (Time Frame - Up to approximately 60 months): Time to deterioration from baseline in European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) scores. Scale scores range from 0-100. For functioning and global health status/QoL scales, higher scores indicate better functioning or global health status/QoL. For symptom scales, higher scores indicate greater symptom burden.
5. Progression Free Survival (PFS) as Assessed by Investigator per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1) (Time Frame - Until progression or death, up to approximately 60 months): PFS is defined as time from date of randomization until the date of first objective progressive disease (PD) by investigator assessment according to RECIST v1.1 or death from any cause, whichever comes first.
6. Objective Response Rate (ORR) as Assessed by Investigator per RECIST Version 1.1 (Time Frame - Up to approximately 60 months): ORR is defined as the proportion of participants who achieve a complete response (CR) or partial response (PR) that is confirmed at least 4 weeks after initial documentation of response.
7. Duration of Response (DOR) as Assessed by BICR and Investigator per RECIST Version 1.1 (Time Frame - Until progression or death, up to approximately 60 months): DOR is defined as the time from the first documentation of CR or PR to the earlier of the first documentation of objective PD or death from any cause (whichever comes first).
8. Percentage of Participants Experiencing Treatment-emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs) (Time Frame - First dose date up to 30 days post last dose, up to approximately 60 months)
9. Percentage of Participants Experiencing Clinically Significant Laboratory and/or Vital Sign Abnormalities (Time Frame - First dose date up to 30 days post last dose, up to approximately 60 months)
Experimental: Sacituzumab Govitecan-hziy (SG) Participants will receive SG at a dose of 10 mg/kg infusion on Days 1 and 8 of a 21-day cycle.
Active Comparator: Treatment of Physician's Choice (TPC) Participants will receive TPC determined prior to randomization to 1 of the 3 allowed regimens:
paclitaxel 80 mg/m^2 over 1 hour (± 10 minutes) on Days 1, 8, and 15 of a 28-day cycle.
nab-Paclitaxel 100 mg/m^2 over 30 minutes (± 10 minutes) on Days 1, 8, and 15 of a 28-day cycle.
capecitabine at 1000-1250 mg/m^2 twice daily for 2 weeks followed by a 1-week rest period of a 21-day cycle.
Sie können folgenden Inhalt einem Kollegen empfehlen:
"Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy"
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