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JOURNAL ONKOLOGIE – STUDIE
EPCORE DLBCL-2

A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

Rekrutierend

NCT-Nummer:
NCT05578976

Studienbeginn:
Februar 2023

Letztes Update:
09.08.2024

Wirkstoff:
Epcoritamab, Cyclophosphamide, Rituximab, Vincristine, Doxorubicin, Prednisone

Indikation (Clinical Trials):
Lymphoma, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse

Geschlecht:
Alle

Altersgruppe:
Erwachsene (18+)

Phase:
Phase 3

Sponsor:
Genmab

Collaborator:
AbbVie

Studienleiter

ABBVIE INC.
Study Director
AbbVie

Kontakt

Studienlocations
(3 von 317)

University of Arizona Cancer Center - North Campus /ID# 227463
85719-1478 Tucson
United StatesRekrutierend» Google-Maps
University of Arkansas for Medical Sciences /ID# 225703
72205 Little Rock
United StatesRekrutierend» Google-Maps
CBCC Global Research, Inc. /ID# 262037
93309 Bakersfield
United StatesRekrutierend» Google-Maps
Alta Bates Summit Medical Center for Research /ID# 229427
94705 Berkeley
United StatesRekrutierend» Google-Maps
Orange Coast Memorial Medical Center /ID# 229632
92708 Fountain Valley
United StatesRekrutierend» Google-Maps
Providence - St. Jude Medical Center /ID# 262042
92835 Fullerton
United StatesRekrutierend» Google-Maps
Saddleback Memorial Medical Center /ID# 229631
92653-3689 Laguna Hills
United StatesRekrutierend» Google-Maps
Long Beach Memorial Medical Ct /ID# 228996
90806-1701 Long Beach
United StatesRekrutierend» Google-Maps
Cancer and Blood Speciality Clinic - Los Alamitos /ID# 262032
90720-3309 Los Alamitos
United StatesRekrutierend» Google-Maps
University of Southern California /ID# 225443
90033 Los Angeles
United StatesRekrutierend» Google-Maps
University of California, Los Angeles /ID# 226887
90095 Los Angeles
United StatesRekrutierend» Google-Maps
Kaiser Permanente, Waterpark III Institute for Health Research /ID# 228618
80014 Aurora
United StatesRekrutierend» Google-Maps
Cancer Specialists of North Florida /ID# 226826
32256 Jacksonville
United StatesRekrutierend» Google-Maps
UF Health Cancer Center at Orlando Health /ID# 232626
32806 Orlando
United StatesRekrutierend» Google-Maps
Straub Medical Center /ID# 229464
96813-3097 Honolulu
United StatesRekrutierend» Google-Maps
Southern IL Univ School of Med /ID# 228999
62702 Springfield
United StatesRekrutierend» Google-Maps
Carle Cancer Institute /ID# 228338
61801-1645 Urbana
United StatesRekrutierend» Google-Maps
Parkview Comprehensive Cancer Center /ID# 227026
46845 Fort Wayne
United StatesRekrutierend» Google-Maps
Goshen Center for Cancer Care /ID# 225534
46526 Goshen
United StatesAbgeschlossen» Google-Maps
Mission Cancer and Blood /ID# 261945
50314-3017 Des Moines
United StatesRekrutierend» Google-Maps
Cancer Center of Kansas /ID# 261983
67214 Wichita
United StatesRekrutierend» Google-Maps
Norton Cancer Institute - St. Matthews /ID# 225420
40207 Louisville
United StatesRekrutierend» Google-Maps
University of Maryland Medical Center /ID# 225421
21201 Baltimore
United StatesRekrutierend» Google-Maps
Johns Hopkins Hospital /ID# 225369
21287 Baltimore
United StatesRekrutierend» Google-Maps
American Oncology Partners of Maryland /ID# 226859
20817 Bethesda
United StatesRekrutierend» Google-Maps
UMass Memorial Medical Center /ID# 226939
01605 Worcester
United StatesRekrutierend» Google-Maps
Trinity Health St. Joseph Mercy Ann Arbor /ID# 228206
48197-1051 Ypsilanti
United StatesRekrutierend» Google-Maps
Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 226680
55416 Saint Louis Park
United StatesRekrutierend» Google-Maps
Intermountain Health - St Vincent Regional Hospital - Cancer Centers of Montana /ID# 259014
59102 Billings
United StatesRekrutierend» Google-Maps
NHO Revive Research Institute, LLC /ID# 261113
68506 Lincoln
United StatesRekrutierend» Google-Maps
Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 226654
08816 East Brunswick
United StatesRekrutierend» Google-Maps
New York Cancer and Blood Specialists- Eastchester, Bronx /ID# 265396
10469 Bronx
United StatesRekrutierend» Google-Maps
Roswell Park Cancer Institute /ID# 239127
14263 Buffalo
United StatesRekrutierend» Google-Maps
NYU Langone Hospital - Long Island /ID# 262412
11501 Mineola
United StatesRekrutierend» Google-Maps
New York Cancer and Blood Specialists- New Hyde Park /ID# 265392
11042 New Hyde Park
United StatesRekrutierend» Google-Maps
NYU Langone - Laura and Isaac Perlmutter Cancer Center /ID# 226141
10016-4744 New York
United StatesRekrutierend» Google-Maps
New York Cancer and Blood Specialists- Manhattan /ID# 265391
10028 New York
United StatesRekrutierend» Google-Maps
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 225379
10065-6007 New York
United StatesRekrutierend» Google-Maps
New York Cancer and Blood Specialists /ID# 261114
11776-8060 Port Jefferson Station
United StatesRekrutierend» Google-Maps
Novant Health Presbyterian Medical Center /ID# 227753
28204 Charlotte
United StatesRekrutierend» Google-Maps
East Carolina University - Brody School of Medicine /ID# 225992
27834 Greenville
United StatesRekrutierend» Google-Maps
Novant Health Forsyth Medical Center /ID# 228339
27103 Winston-Salem
United StatesRekrutierend» Google-Maps
University of Cincinnati /ID# 225374
45267 Cincinnati
United StatesRekrutierend» Google-Maps
Kaiser Permanente - Northwest /ID# 225488
97227 Portland
United StatesRekrutierend» Google-Maps
Millennium Research & Clinical Development /ID# 228284
77339-6008 Kingwood
United StatesRekrutierend» Google-Maps
Joe Arrington Cancer Research /ID# 227217
79410 Lubbock
United StatesRekrutierend» Google-Maps
Baylor Scott & White Medical Center- Temple /ID# 225935
76508-0001 Temple
United StatesRekrutierend» Google-Maps
Intermountain Medical Center /ID# 231184
84107-5701 Murray
United StatesRekrutierend» Google-Maps
University of Virginia Cancer Center - West Complex /ID# 225433
22903-3363 Charlottesville
United StatesRekrutierend» Google-Maps
Vista Oncology - East Olympia /ID# 229375
98506-5028 Olympia
United StatesRekrutierend» Google-Maps
MultiCare Institute for Research & Innovation /ID# 225432
98405 Tacoma
United StatesRekrutierend» Google-Maps
MultiCare Regional Cancer Center - Tacoma /ID# 265285
98405 Tacoma
United StatesRekrutierend» Google-Maps
Liverpool Hospital /ID# 230072
2170 Liverpool
AustraliaRekrutierend» Google-Maps
Royal Adelaide Hospital /ID# 225683
5000 Adelaide
AustraliaRekrutierend» Google-Maps
Monash Medical Centre /ID# 225680
3168 Clayton
AustraliaRekrutierend» Google-Maps
Austin Health /ID# 225716
3084 Heidelberg
AustraliaRekrutierend» Google-Maps
The Alfred Hospital /ID# 225999
3004 Melbourne
AustraliaRekrutierend» Google-Maps
Hollywood Private Hospital /ID# 251837
6009 Nedlands
AustraliaRekrutierend» Google-Maps
Perth Blood Institute Ltd /ID# 225679
6009 Nedlands
AustraliaRekrutierend» Google-Maps
Royal Perth Hospital /ID# 226583
6000 Perth
AustraliaRekrutierend» Google-Maps
Universitaetsklinikum St. Poelten /ID# 234016
3100 Sankt Poelten
AustriaRekrutierend» Google-Maps
Medizinische Universitaet Wien /ID# 252095
1090 Vienna
AustriaRekrutierend» Google-Maps
Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 228360
5020 Salzburg
AustriaRekrutierend» Google-Maps
Cliniques Universitaires UCL Saint-Luc /ID# 225737
1200 Woluwe-Saint-Lambert
BelgiumRekrutierend» Google-Maps
Hospital La Louviere Site Jolimont - Helora /ID# 225738
7100 La Louvière
BelgiumRekrutierend» Google-Maps
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 225742
5530 Yvoir
BelgiumRekrutierend» Google-Maps
Universitair Ziekenhuis Leuven /ID# 225951
3000 Leuven
BelgiumRekrutierend» Google-Maps
Institut Jules Bordet /ID# 225954
1070 Anderlecht
BelgiumRekrutierend» Google-Maps
AZ Sint-Jan Brugge /ID# 225735
8000 Brugge
BelgiumRekrutierend» Google-Maps
Hospital de Clinicas da Universidade Federal do Parana /ID# 226027
80060-900 Curitiba
BrazilRekrutierend» Google-Maps
Hospital Amaral Carvalho - Fundacao Doutor Amaral Carvalho /ID# 226065
17210-070 Jaú
BrazilRekrutierend» Google-Maps
Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 226809
01509-900 São Paulo
BrazilRekrutierend» Google-Maps
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein /ID# 252832
05652-900 São Paulo
BrazilRekrutierend» Google-Maps
Instituto Nacional de Cancer (INCA) /ID# 226026
20231-050 Rio de Janeiro
BrazilRekrutierend» Google-Maps
Real e Benemérita Associação Portuguesa de Beneficência /ID# 226023
01323-001 Sao Paulo
BrazilRekrutierend» Google-Maps
Hospital Alemao Oswaldo Cruz /ID# 252833
01323-020 Sao Paulo
BrazilRekrutierend» Google-Maps
Instituto D'Or de Pesquisa e Ensino - Regional Sao Paulo /ID# 262394
01401-002 Sao Paulo
BrazilRekrutierend» Google-Maps
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 226048
05403-000 Sao Paulo
BrazilRekrutierend» Google-Maps
SHAT Hematologic Diseases /ID# 250102
1797 Sofia
BulgariaRekrutierend» Google-Maps
UMHAT Sveti Georgi /ID# 245780
4002 Plovdiv
BulgariaRekrutierend» Google-Maps
Acibadem City Clinic Tokuda University Hospital EAD /ID# 244616
1407 Sofia
BulgariaRekrutierend» Google-Maps
UMHAT Sveti Ivan Rilski /ID# 244615
1431 Sofia
BulgariaRekrutierend» Google-Maps
Tom Baker Cancer Centre /ID# 226077
T2N 4N2 Calgary
CanadaRekrutierend» Google-Maps
BC Cancer - Vancouver /ID# 230573
V5Z 1L3 Vancouver
CanadaRekrutierend» Google-Maps
William Osler Health System /ID# 250973
L6R 3J7 Brampton
CanadaRekrutierend» Google-Maps
Juravinski Cancer Centre /ID# 226084
L8V 1C3 Hamilton
CanadaRekrutierend» Google-Maps
Saskatoon Cancer Centre /ID# 226082
S7N 4H4 Saskatoon
CanadaRekrutierend» Google-Maps
The Fifth Medical Center of PLA General Hospital /ID# 230941
100071 Beijing
ChinaRekrutierend» Google-Maps
Beijing Cancer Hospital /ID# 229819
100142 Beijing
ChinaRekrutierend» Google-Maps
Peking University Third Hospital /ID# 230975
100191 Beijing
ChinaRekrutierend» Google-Maps
Fujian Provincial Cancer Hospital /ID# 238430
350014 Fuzhou
ChinaRekrutierend» Google-Maps
The First Affiliated Hospital of Xiamen University /ID# 238426
361003 Xiamen
ChinaRekrutierend» Google-Maps
Sun Yat-Sen University Cancer Center /ID# 238371
510060 Guangzhou
ChinaRekrutierend» Google-Maps
Guangdong Provincial People's Hospital /ID# 230945
510080 Guangzhou
ChinaRekrutierend» Google-Maps
Nanfang Hospital of Southern Medical University /ID# 238436
510515 Guangzhou
ChinaRekrutierend» Google-Maps
Harbin Medical University Cancer Hospital /Id# 241755
150081 Harbin
ChinaRekrutierend» Google-Maps
Henan Cancer Hospital /ID# 230398
450008 Zhengzhou
ChinaRekrutierend» Google-Maps
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 234152
430022 Wuhan
ChinaRekrutierend» Google-Maps
Hubei Cancer Hospital /ID# 232256
430079 Wuhan
ChinaRekrutierend» Google-Maps
The First Affiliated Hospital of Soochow University /ID# 232569
215006 Suzhou
ChinaRekrutierend» Google-Maps
The Affiliated Hospital of Xuzhou Medical College /ID# 233174
221006 Xuzhou
ChinaRekrutierend» Google-Maps
The First Affiliated Hospital of Nanchang University /ID# 230399
330006 Nanchang
ChinaRekrutierend» Google-Maps
Jiangxi Provincial Cancer Hospital /ID# 233379
330029 Nanchang
ChinaRekrutierend» Google-Maps
The First Hospital of Jilin University /ID# 239618
130021 Changchun
ChinaRekrutierend» Google-Maps
The First Hospital of China Medical University /ID# 233201
110001 Shenyang
ChinaRekrutierend» Google-Maps
Shandong Cancer Hospital /ID# 233200
251601 Jinan
ChinaRekrutierend» Google-Maps
Fudan University Cancer Hospital /ID# 251516
200032 Shanghai
ChinaRekrutierend» Google-Maps
Tianjin Cancer Hospital /ID# 230974
300000 Tianjin
ChinaRekrutierend» Google-Maps
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 259904
300020 Tianjin
ChinaRekrutierend» Google-Maps
Ansprechpartner:
Site Coordinator
Phone: 022-23909999
» Ansprechpartner anzeigen
The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 230387
310003 Hangzhou
ChinaRekrutierend» Google-Maps
The second affiliated hospital of Zhejiang University school of medicine /ID# 231249
310009 Hangzhou
ChinaRekrutierend» Google-Maps
Zhejiang Cancer hospital /ID# 231388
310022 Hangzhou
ChinaRekrutierend» Google-Maps
Clinical Hospital Dubrava /ID# 251809
10000 Zagreb
CroatiaRekrutierend» Google-Maps
Klinicka bolnica Merkur /ID# 252481
10000 Zagreb
CroatiaRekrutierend» Google-Maps
Klinicki bolnicki centar Zagreb /ID# 250709
10000 Zagreb
CroatiaRekrutierend» Google-Maps
Klinicki bolnicki centar Rijeka /ID# 251811
51000 Rijeka
CroatiaRekrutierend» Google-Maps
Klinicki Bolnicki Centar (KBC) Split /ID# 250729
21000 Split
CroatiaAktiv, nicht rekrutierend» Google-Maps
Opca bolnica Dr. Josip Bencevic /ID# 251812
35000 Slavonski Brod
CroatiaRekrutierend» Google-Maps
Fakultni nemocnice Hradec Kralove /ID# 225955
500 05 Hradec Kralove
CzechiaRekrutierend» Google-Maps
Fakultni Nemocnice Ostrava /ID# 225957
708 52 Ostrava
CzechiaRekrutierend» Google-Maps
Fakultni nemocnice Brno /ID# 225953
613 00 Brno
CzechiaRekrutierend» Google-Maps
Duplicate_Fakultni Nemocnice v Motole /ID# 225958
150 00 Prague
CzechiaRekrutierend» Google-Maps
Fakultni nemocnice Kralovske Vinohrady /ID# 225956
100 34 Praha
CzechiaRekrutierend» Google-Maps
Vseobecna fakultni nemocnice v Praze /ID# 225396
128 08 Praha
CzechiaRekrutierend» Google-Maps
Rigshospitalet /ID# 226576
2100 Copenhagen Ø
DenmarkRekrutierend» Google-Maps
Aarhus Universitetshospital - Skejby /ID# 226594
8200 Aarhus
DenmarkRekrutierend» Google-Maps
Roskilde Sygehus /ID# 226597
4000 Roskilde
DenmarkRekrutierend» Google-Maps
Odense University Hospital /ID# 226593
5000 Odense
DenmarkRekrutierend» Google-Maps
Sygehus Lillebalt, Vejle /ID# 226592
7100 Vejle
DenmarkRekrutierend» Google-Maps
CHU de Nice - Hôpital Archet 1 /ID# 226127
06200 Nice
FranceRekrutierend» Google-Maps
Institut Paoli-Calmettes /ID# 226557
13009 Marseille
FranceRekrutierend» Google-Maps
CHU de Rennes - PONTCHAILLOU /ID# 228207
35000 Rennes
FranceRekrutierend» Google-Maps
CHU Limoges - Dupuytren 1 /ID# 234235
87042 Limoges CEDEX 1
FranceRekrutierend» Google-Maps
Centre Henri Becquerel /ID# 226103
76038 Rouen
FranceRekrutierend» Google-Maps
CHU Montpellier - Hopital Saint Eloi /ID# 228191
34295 Montpellier Cedex 5
FranceRekrutierend» Google-Maps
CHU Grenoble - Hopital Michallon /ID# 226128
38700 La Tronche
FranceRekrutierend» Google-Maps
CHRU Nancy - Hopitaux de Brabois /ID# 226102
54500 Vandoeuvre-les-Nancy
FranceRekrutierend» Google-Maps
CHRU Lille - Hopital Claude Huriez /ID# 226101
59037 Lille
FranceRekrutierend» Google-Maps
Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 226560
94010 Creteil
FranceRekrutierend» Google-Maps
CHU de Nantes, Hotel Dieu -HME /ID# 226125
44000 Nantes
FranceRekrutierend» Google-Maps
Centre Hospitalier de la Cote Basque /ID# 249143
64100 Bayonne
FranceRekrutierend» Google-Maps
HCL - Hopital Lyon Sud /ID# 227086
69495 Pierre Benite CEDEX
FranceRekrutierend» Google-Maps
CHU Amiens-Picardie Site Sud /ID# 238347
80054 Amiens CEDEX 1
FranceRekrutierend» Google-Maps
CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 243899
85000 La Roche Sur Yon
FranceRekrutierend» Google-Maps
CHU Poitiers - La miletrie /ID# 226578
86000 Poitiers
FranceRekrutierend» Google-Maps
CHU de CAEN - Hopital de la Cote de Nacre /ID# 226582
14033 Caen
FranceRekrutierend» Google-Maps
AP-HP - Hopital Saint-Louis /ID# 226126
75010 Paris
FranceRekrutierend» Google-Maps
Institut Curie - site CLCC René Huguenin /ID# 253519
92210 Saint-cloud
FranceRekrutierend» Google-Maps
General Hospital of Athens Laiko /ID# 225399
11527 Athens
GreeceRekrutierend» Google-Maps
Alexandra General Hospital /ID# 225402
11528 Athens
GreeceRekrutierend» Google-Maps
University General Hospital Attikon /ID# 225401
12462 Athens
GreeceRekrutierend» Google-Maps
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 225416
10676 Athens
GreeceRekrutierend» Google-Maps
University General Hospital of Ioannina /ID# 225400
45500 Ioannina
GreeceRekrutierend» Google-Maps
General University Hospital of Thessaloniki AXEPA /ID# 225398
54636 Thessaloniki
GreeceRekrutierend» Google-Maps
Theageneio Anticancer Hospital /ID# 225516
54639 Thessaloniki
GreeceRekrutierend» Google-Maps
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 257189
9024 Gyor
HungaryRekrutierend» Google-Maps
Debreceni Egyetem-Klinikai Kozpont /ID# 226821
4032 Debrecen
HungaryRekrutierend» Google-Maps
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 245938
7400 Kaposvár
HungaryRekrutierend» Google-Maps
Tolna Varmegyei Balassa Janos Korhaz /ID# 250063
7100 Szekszard
HungaryRekrutierend» Google-Maps
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 226846
9700 Szombathely
HungaryRekrutierend» Google-Maps
Semmelweis Egyetem /ID# 227239
1085 Budapest
HungaryRekrutierend» Google-Maps
Orszagos Onkologiai Intezet /ID# 227294
1122 Budapest
HungaryRekrutierend» Google-Maps
Szegedi Tudományegyetem /ID# 226838
6720 Szeged
HungaryRekrutierend» Google-Maps
Rambam Health Care Campus /ID# 225981
3109601 Haifa
IsraelRekrutierend» Google-Maps
Meir Medical Center /ID# 225612
4428164 Kfar Saba
IsraelRekrutierend» Google-Maps
Assuta Tel Aviv Medical Center /ID# 226066
6971028 Tel Aviv
IsraelRekrutierend» Google-Maps
The Chaim Sheba Medical Center /ID# 225600
5265601 Ramat Gan
IsraelRekrutierend» Google-Maps
Tel Aviv Sourasky Medical Center /ID# 225891
6423906 Tel Aviv
IsraelRekrutierend» Google-Maps
Shaare Zedek Medical Center /ID# 259796
91031 Jerusalem
IsraelRekrutierend» Google-Maps
Rabin Medical Center /ID# 225862
4941492 Haifa
IsraelRekrutierend» Google-Maps
Ospedale Casa Sollievo Della Sofferenza /ID# 225554
71013 San Giovanni Rotondo
ItalyRekrutierend» Google-Maps
I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 225548
70124 Bari
ItalyRekrutierend» Google-Maps
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRCCS /ID# 252192
47014 Meldola
ItalyRekrutierend» Google-Maps
Azienda Ospedaliera Universitaria Federico II /ID# 225543
80131 Napoli
ItalyRekrutierend» Google-Maps
Ospedale San Raffaele IRCCS /ID# 225555
20132 Milan
ItalyRekrutierend» Google-Maps
IEO -Istituto Europeo di Oncologia /ID# 225545
20141 Milan
ItalyRekrutierend» Google-Maps
Istituto di Candiolo Fondazione del Piemonte per l'Oncologia IRCCS /ID# 225751
10060 Candiolo
ItalyRekrutierend» Google-Maps
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo /ID# 225542
15100 Alessandria
ItalyRekrutierend» Google-Maps
Centro di Riferimento Oncologico /ID# 225553
33081 Aviano
ItalyAbgeschlossen» Google-Maps
ASST Spedali civili di Brescia /ID# 225549
25123 Brescia
ItalyRekrutierend» Google-Maps
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara /ID# 225773
28100 Novara
ItalyRekrutierend» Google-Maps
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 225541
90146 Palermo
ItalyRekrutierend» Google-Maps
Azienda Ospedaliero Universitaria Pisana /ID# 225575
56126 Pisa
ItalyRekrutierend» Google-Maps
Ospedale Santa Maria delle Croci /ID# 225571
48121 Ravenna
ItalyRekrutierend» Google-Maps
NHO Nagoya Medical Center /ID# 230677
460-0001 Nagoya-shi
JapanRekrutierend» Google-Maps
Aichi Cancer Center Hospital /ID# 226090
464-8681 Nagoya-shi
JapanRekrutierend» Google-Maps
National Cancer Center Hospital East /ID# 250151
277-8577 Kashiwa-shi
JapanRekrutierend» Google-Maps
Matsuyama Red Cross Hospital /ID# 251068
790-8524 Matsuyama-shi
JapanRekrutierend» Google-Maps
National Hospital Organization Kyushu Cancer Center /ID# 251622
811-1395 Fukuoka-shi
JapanRekrutierend» Google-Maps
Kyushu University Hospital /ID# 226091
812-8582 Fukuoka-shi
JapanRekrutierend» Google-Maps
Fukushima Medical University Hospital /ID# 250869
960-1295 Fukushima-shi
JapanRekrutierend» Google-Maps
Hokkaido University Hospital /ID# 250149
060-8648 Sapporo-shi
JapanRekrutierend» Google-Maps
Kobe City Medical Center General Hospital /ID# 250597
650-0047 Kobe-shi
JapanRekrutierend» Google-Maps
University of Tsukuba Hospital /ID# 251282
305-8576 Tsukuba-shi
JapanRekrutierend» Google-Maps
Kanazawa University Hospital /ID# 251770
920-8641 Kanazawa-shi
JapanRekrutierend» Google-Maps
Kagoshima University Hospital /ID# 250163
890-8520 Kagoshima-shi
JapanRekrutierend» Google-Maps
Tokai University Hospital /ID# 251281
259-1193 Isehara
JapanRekrutierend» Google-Maps
Tohoku University Hospital /ID# 250150
9808574 Sendai-shi
JapanRekrutierend» Google-Maps
Kindai University Hospital /ID# 250160
589-8511 Osakasayama-shi
JapanRekrutierend» Google-Maps
Osaka University Hospital /ID# 251283
565-0871 Suita-shi
JapanRekrutierend» Google-Maps
National Cancer Center Hospital /ID# 226089
104-0045 Chuo-ku
JapanRekrutierend» Google-Maps
The Cancer Institute Hospital Of JFCR /ID# 230269
135-8550 Koto-ku
JapanRekrutierend» Google-Maps
Yamagata University Hospital /ID# 230003
990-9585 Yamagata-shi
JapanRekrutierend» Google-Maps
Okayama University Hospital /ID# 250161
700-8558 Okayama
JapanRekrutierend» Google-Maps
Inje University - Busan Paik Hospital /ID# 232262
47392 Busan
Korea, Republic ofRekrutierend» Google-Maps
Seoul National University Bundang Hospital /ID# 225763
13620 Seongnam-si
Korea, Republic ofRekrutierend» Google-Maps
Keimyung University Dongsan Hospital /ID# 232264
42601 Daegu
Korea, Republic ofRekrutierend» Google-Maps
Dong-A University Medical Center /ID# 228451
49201 Busan
Korea, Republic ofRekrutierend» Google-Maps
Jeonbuk National University Hospital /ID# 232263
54907 Jeonju
Korea, Republic ofRekrutierend» Google-Maps
Seoul National University Hospital /ID# 225760
03080 Seoul
Korea, Republic ofRekrutierend» Google-Maps
Asan Medical Center /ID# 225758
05505 Seoul
Korea, Republic ofRekrutierend» Google-Maps
Samsung Medical Center /ID# 225759
06351 Seoul
Korea, Republic ofRekrutierend» Google-Maps
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 225761
06591 Seoul
Korea, Republic ofRekrutierend» Google-Maps
Ulsan University Hospital /ID# 226971
44033 Ulsan
Korea, Republic ofRekrutierend» Google-Maps
Flevo Ziekenhuis /ID# 229606
1315 RA Almere
NetherlandsRekrutierend» Google-Maps
Gelre Ziekenhuizen /ID# 229762
7334 DZ Apeldoorn
NetherlandsRekrutierend» Google-Maps
Amphia Ziekenhuis /ID# 229550
4818 CK Breda
NetherlandsRekrutierend» Google-Maps
Spaarne Gasthuis, Haarlem Zuid /ID# 229621
2035 RC Haarlem
NetherlandsRekrutierend» Google-Maps
Dijklander Ziekenhuis /ID# 229900
1624 NP Hoorn Nh
NetherlandsRekrutierend» Google-Maps
Zaans Medisch Centrum /ID# 230614
1502 DV Zaandam
NetherlandsRekrutierend» Google-Maps
Noordwest Ziekenhuisgroep /ID# 230613
1815 JD Alkmaar
NetherlandsRekrutierend» Google-Maps
Meander Medisch Centrum /ID# 229608
3813 TZ Amersfoort
NetherlandsRekrutierend» Google-Maps
Vrije Universiteit Medisch Centrum /ID# 225608
1081 HV Amsterdam
NetherlandsRekrutierend» Google-Maps
Onze Lieve Vrouwe Gasthuis /ID# 229761
1091 AC Amsterdam
NetherlandsRekrutierend» Google-Maps
Albert Schweitzer Ziekenhuis /ID# 229560
3318 AT Dordrecht
NetherlandsRekrutierend» Google-Maps
Catharina Ziekenhuis /ID# 230465
5623 EJ Eindhoven
NetherlandsRekrutierend» Google-Maps
Maxima Medisch Centrum /ID# 225603
5631 BM Eindhoven
NetherlandsRekrutierend» Google-Maps
Medisch Spectrum Twente /ID# 225610
7512 KZ Enschede
NetherlandsRekrutierend» Google-Maps
Medisch Centrum Leeuwarden /ID# 225605
8934 AD Leeuwarden
NetherlandsRekrutierend» Google-Maps
Leids Universitair Medisch Centrum /ID# 225606
2333 ZA Leiden
NetherlandsRekrutierend» Google-Maps
Maastricht Universitair Medisch Centrum /ID# 225607
6229 HX Maastricht
NetherlandsRekrutierend» Google-Maps
St. Antonius Ziekenhuis /ID# 229901
3435 CM Nieuwegein
NetherlandsRekrutierend» Google-Maps
Canisius-Wilhelmina Ziekenhuis /ID# 231291
6532 SZ Nijmegen
NetherlandsRekrutierend» Google-Maps
Elisabeth Tweesteden Ziekenhuis /ID# 229773
5022 GC Tilburg
NetherlandsRekrutierend» Google-Maps
Haaglanden Medisch Centrum /ID# 229686
2512 VA Den Haag
NetherlandsRekrutierend» Google-Maps
Deventer Ziekenhuis /ID# 229937
7416 SE Deventer
NetherlandsRekrutierend» Google-Maps
Universitair Medisch Centrum Groningen /ID# 225602
9713 GZ Groningen
NetherlandsRekrutierend» Google-Maps
Jeroen Bosch Ziekenhuis /ID# 229765
5223 GZ S Hertogenbosch
NetherlandsRekrutierend» Google-Maps
Diakonessenhuis /ID# 251793
3582 KE Utrecht
NetherlandsRekrutierend» Google-Maps
North Shore Hospital /ID# 250992
0622 Takapuna
New ZealandRekrutierend» Google-Maps
Christchurch Hospital /ID# 250993
8011 Christchurch
New ZealandRekrutierend» Google-Maps
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka /ID# 228723
76-200 Slupsk
PolandRekrutierend» Google-Maps
Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 225986
25-734 Kielce
PolandRekrutierend» Google-Maps
Szpital Kliniczny MSWiA z Warminsko-Mazurskim Centrum Onkologii /ID# 225985
10-228 Olsztyn
PolandRekrutierend» Google-Maps
ARS-MEDICAL Sp. z o.o. /ID# 225848
64-920 Pila
PolandRekrutierend» Google-Maps
Centrum Medyczne Pratia Poznan /ID# 227236
60-185 Skorzewo
PolandRekrutierend» Google-Maps
2CA-Braga, Hospital de Braga /ID# 249112
4710-243 Braga
PortugalRekrutierend» Google-Maps
IPO Lisboa FG, EPE /ID# 249109
1099-023 Lisboa
PortugalRekrutierend» Google-Maps
Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 249111
1649-035 Lisboa
PortugalRekrutierend» Google-Maps
IPO Porto FG, EPE /ID# 249110
4200-072 Porto
PortugalRekrutierend» Google-Maps
Hospital Erasto Gaertner /ID# 262593
81520-060 Curitiba
Puerto RicoRekrutierend» Google-Maps
Hematology and Oncology Institute /ID# 230054
00674 Manati
Puerto RicoRekrutierend» Google-Maps
Pan American Center for Oncology Trials, LLC /ID# 230052
00935 Rio Piedras
Puerto RicoRekrutierend» Google-Maps
Narodny onkologicky ustav /ID# 238847
833 10 Bratislava
SlovakiaRekrutierend» Google-Maps
Univerzitna nemocnica Martin /ID# 240828
036 01 Martin
SlovakiaRekrutierend» Google-Maps
Wits Clinical Research /ID# 227799
1864 Johannesburg
South AfricaRekrutierend» Google-Maps
Wits Clinical Research /ID# 227803
1864 Johannesburg
South AfricaRekrutierend» Google-Maps
Alberts Cellular Therapy /ID# 227798
0044 Pretoria
South AfricaRekrutierend» Google-Maps
University of Cape Town /ID# 227802
7925 Cape Town
South AfricaRekrutierend» Google-Maps
Haemalife Inc. /ID# 243391
7580 Kuilsrivier
South AfricaRekrutierend» Google-Maps
Instituto Catalan de Oncologia (ICO) Badalona /ID# 228063
08916 Badalona
SpainRekrutierend» Google-Maps
Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 227393
08907 L'Hospitalet de Llobregat
SpainRekrutierend» Google-Maps
Hospital Universitario Reina Sofia /ID# 225806
14004 Córdoba
SpainRekrutierend» Google-Maps
Hospital Clinico Universitario Virgen de la Arrixaca /ID# 255381
30120 El Palmar
SpainRekrutierend» Google-Maps
Clinica Universidad de Navarra - Pamplona /ID# 225809
31008 Pamplona
SpainRekrutierend» Google-Maps
Hospital Parc de Salut del Mar /ID# 225810
08003 Barcelona
SpainRekrutierend» Google-Maps
Hospital Universitario Vall d'Hebron /ID# 225811
08035 Barcelona
SpainRekrutierend» Google-Maps
Hospital Clinic de Barcelona /ID# 226651
08036 Barcelona
SpainRekrutierend» Google-Maps
Hospital Santa Creu i Sant Pau /ID# 225813
08041 Barcelona
SpainRekrutierend» Google-Maps
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 228228
28027 Madrid
SpainRekrutierend» Google-Maps
Hospital Universitario Infanta Leonor /ID# 225816
28031 Madrid
SpainRekrutierend» Google-Maps
Hospital Universitario Ramon y Cajal /ID# 241750
28034 Madrid
SpainRekrutierend» Google-Maps
Hospital Universitario Fundacion Jimenez Diaz /ID# 225804
28040 Madrid
SpainRekrutierend» Google-Maps
Hospital Universitario 12 de Octubre /ID# 225815
28041 Madrid
SpainRekrutierend» Google-Maps
Hospital Clinico Universitario de Valencia /ID# 225818
46010 Valencia
SpainRekrutierend» Google-Maps
Skane University Hospital Lund /ID# 227285
224 84 Lund
SwedenRekrutierend» Google-Maps
Linkoping University Hospital /ID# 233521
581 85 Linkoping
SwedenRekrutierend» Google-Maps
Karolinska University Hospital Solna /ID# 229284
171 64 Solna
SwedenRekrutierend» Google-Maps
Sodra Alvsborgs sjukhus /ID# 228885
501 82 Boras
SwedenRekrutierend» Google-Maps
Sahlgrenska Universitetssjukhuset /ID# 250089
413 46 Göteborg
SwedenRekrutierend» Google-Maps
Kantonsspital Aarau AG /ID# 229112
5001 Aarau
SwitzerlandRekrutierend» Google-Maps
KSW Kantonsspital Winterthur /ID# 241631
8400 Winterthur
SwitzerlandRekrutierend» Google-Maps
Kaohsiung Chang Gung Memorial Hospital /ID# 226670
833 Kaohsiung City
TaiwanRekrutierend» Google-Maps
Taichung Veterans General Hospital /ID# 226674
40705 Taichung
TaiwanRekrutierend» Google-Maps
National Cheng Kung University Hospital /ID# 226671
704 Tainan
TaiwanRekrutierend» Google-Maps
China Medical University Hospital /ID# 226188
40447 Taichung
TaiwanRekrutierend» Google-Maps
Ankara Universitesi Fakultesi /ID# 227331
06620 Ankara
TurkeyRekrutierend» Google-Maps
Karadeniz University /ID# 226573
61000 Trabzon
TurkeyAbgeschlossen» Google-Maps
Anadolu Saglik Merkezi /ID# 225777
41455 Dilovası
TurkeyRekrutierend» Google-Maps
Inonu University Medical Faculty /ID# 226572
44280 Malatya
TurkeyRekrutierend» Google-Maps
Ondokuz Mayis Universitesi /ID# 251247
55139 Samsun
TurkeyRekrutierend» Google-Maps
Baskent Universitesi Adana Uyg. ve Arast. Merkezi Yuregir Baskent Hastanesi /ID# 225921
01240 Yuregir
TurkeyRekrutierend» Google-Maps
Imperial College Healthcare NHS Trust /ID# 242215
W2 1NY London
United KingdomRekrutierend» Google-Maps
Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 226692
NR4 7UY Norwich
United KingdomAbgeschlossen» Google-Maps
University Hospitals Birmingham NHS Foundation Trust /ID# 229197
B15 2TH Birmingham
United KingdomRekrutierend» Google-Maps
NHS Lothian /ID# 229055
EH3 9HE Edinburgh
United KingdomRekrutierend» Google-Maps
Alle anzeigen

Studien-Informationen

Brief Summary:

B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood

cell responsible for fighting infections). The purpose of this study is to assess the

change in disease activity of epcoritamab when combined with intravenous and oral

rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone

(R-CHOP) or R-CHOP in adult participants globally with diffuse large b-cell lymphoma

(DLBCL). Change in disease activity will be assessed.

Epcoritamab is an investigational drug being developed for the treatment of DLBCL. Study

doctors put the participants in groups called treatment arms. Participants will receive

epcoritamab combined with R-CHOP, followed by epcoritamab or R-CHOP followed by rituximab

will be explored. Approximately 900 adult participants with with newly diagnosed DLBCL

will be enrolled in the study in approximately 315 sites in globally.

In the Arm 1, participants will receive subcutaneous epcoritamab combined with

intravenous and oral R-CHOP followed by subcutaneous epcoritamab in 21-day cycles. In the

Arm 2, participants will receive intravenous and oral R-CHOP followed by intravenous

rituximab in 21-day cycles.

There may be higher treatment burden for participants in this trial compared to their

standard of care. Participants will attend regular visits during the study at an approved

institution (hospital or clinic). The effect of the treatment will be frequently checked

by medical assessments, blood tests, questionnaires and side effects.

Ein-/Ausschlusskriterien

Inclusion Criteria:

- Planned to receive treatment with 6 cycles of standard rituximab, cyclophosphamide,

doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) per investigator

determination.

- Must have newly diagnosed, histologically confirmed CD20+ diffuse large b-cell

lymphoma [DLBCL] (de novo or histologically transformed from a diagnosis of

follicular lymphoma) at most recent representative tumor biopsy based on the

pathology report, with a World Health Organization (WHO) 2016 classification and

including:

- DLBCL, Not Otherwise Specified (NOS).

- High grade B-cell lymphoma with MYC and BCL-2 and/or BCL-6 rearrangement with

DLBCL morphology.

- T-cell/histiocyte-rich large B-cell lymphoma.

- Epstein Barr virus-positive DLBCL, NOS.

- Follicular lymphoma Grade 3b.

Note: The local pathology report must be available at Screening to support CD20+ DLBCL

histology.

Composite/intermediate histology with any of the following components is not allowed:

high grade B-cell lymphoma, NOS; Hodgkin's lymphoma; primary mediastinal (thymic) large

B-cell lymphoma; Burkitt; plasmablastic lymphoma or any CD20- lymphoma, such as

anaplastic lymphoma kinase-positive large B-cell lymphoma, human herpesvirus type

8-positive DLBCL, or primary effusion lymphoma.

- Availability of archival or fresh or paraffin embedded tissue at Screening.

- Must have an IPI score of 2-5. The number of participants with IPI 2 will not exceed

approximately 30% of the overall sample size.

- Must have an Eastern Cooperative Oncology Group (ECOG) performance status score of

0-2 prior to initiating R-CHOP treatment. Note that participant with an initial ECOG

performance status >= 3 may be screened if pre-phase treatment is planned.

Participant may be eligible if ECOG performance status were to improve to 0-2 during

pre-phase treatment.

- Has at least one target lesion defined as:

- >= 1 measurable nodal lesion (long axis > 1.5 cm ) or >= 1 measurable

extra-nodal lesion (long axis > 1 cm) on computed tomography (CT) scan or

magnetic resonance imaging (MRI). AND

- Positron emission tomography (PET)-positive on PET-CT scan.

- Laboratory values meeting the criteria laid out in the protocol.

- Left ventricular ejection fraction must be >= 50% by multi-gated acquisition or

transthoracic echocardiography at Screening.

Exclusion Criteria:

- History of prior systemic anti-lymphoma therapy for diagnosed diffuse large b-cell

lymphoma (DLBCL) including any definitive radiotherapy with curative intent] other

than corticosteroids with or without vincristine during prephase treatment, or

non-curative intent palliative radiotherapy with the stipulation that radiated

lesions cannot be selected as target lesion for response assessment.

- Clinically significant cardiovascular disease as per the protocol.

Studien-Rationale

Primary outcome:

1. Number of Participants with Progression-Free Survival (PFS) with an International Prognostic Index (IPI) of 3-5 (Time Frame - Up to Approximately 46 Months):
PFS is defined as the duration from randomization to the date of disease progression as determined by Lugano 2014 criteria as assessed by Independent Review Committee (IRC), or death due to any cause whichever comes first.



Secondary outcome:

1. Number of Participants with PFS (Time Frame - Up to Approximately 46 Months):
PFS is defined as the duration from randomization to the date of disease progression as determined by Lugano 2014 criteria as assessed by IRC, or death due to any cause, whichever occurs first.

2. Number of Participants with Event-free survival (EFS) (Time Frame - Up to Approximately 46 Months):
EFS is defined as the duration from randomization to the date of disease progression determined by Lugano criteria as assessed by IRC, IRC-assessed PR or SD followed by non protocol-specified NALT, a positive biopsy on or after end-of-treatment (EOT), regardless of whether NAL initiated, or death from any cause.

3. Percentage of Participants with Complete Remission (CR) (Time Frame - On or After to Approximately 28 Weeks):
CR on or after EOT, determined by Lugano 2014 criteria as assessed by IRC.

4. Overall survival (OS) (Time Frame - Up to Approximately 76 Months):
OS is defined as time from randomization until death due to any causes.

5. Percentage of Participants with Minimal Residual Disease (MRD) Negativity (Time Frame - Up to Approximately 46 Months):
The MRD negativity rate is defined as the percentage of participants who achieve MRD negativity prior to the initiation of any non-protocol-specified new anti-lymphoma therapy.

Studien-Arme

  • Experimental: Epcoritamab and R-CHOP
    Participants will receive subcutaneous epcoritamab combined with intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.
  • Experimental: R-CHOP and Rituximab
    Participants will receive intravenous rituximab, cyclophosphamide, doxorubixin hydrochloride, vincristine and oral prednisone (R-CHOP) followed by intravenous rituximab in 21-day cycles.

Geprüfte Regime

  • Epcoritamab (ABBV-GMAB-3013):
    Subcutaneous Injection (SC)
  • Cyclophosphamide:
    Intravenous (IV) Injection
  • Rituximab:
    IV Infusion
  • Vincristine:
    IV Infusion
  • Doxorubicin:
    IV Infusion
  • Prednisone:
    Oral; Tablet

Quelle: ClinicalTrials.gov


Sie können folgenden Inhalt einem Kollegen empfehlen:

"A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)"

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