Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer.
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Studienlocations (3 von 344)
Charite - Universitaetsmedizin Berlin, Campus Virchow 13353 Berlin (Berlin) GermanyRekrutierend» Google-MapsUniversitaetsklinikum Dresden 01307 Dresden (Sachsen) GermanyRekrutierend» Google-MapsKrankenhaus Nordwest GmbH 60488 Frankfurt am Main (Hessen) GermanyRekrutierend» Google-Maps
Haematologisch Onkologische Praxis Eppendorf 20249 Hamburg (Hamburg) GermanyRekrutierend» Google-MapsLeberkrebszentrum Medizinische Hochschule Hannover Carl-Neuberg-Straße 1 30625 Hannover DeutschlandRekrutierend» Google-MapsUniversitaetsklinikum Schleswig-Holstein 24105 Kiel (Schleswig-Holstein) GermanyRekrutierend» Google-MapsUniversitaetsklinikum Leipzig 04103 Leipzig (Sachsen) GermanyRekrutierend» Google-MapsRegional Kliniken Holding Klinikum Ludwigsburg 71640 Ludwigsburg (Baden-Württemberg) GermanyRekrutierend» Google-MapsJohannes Gutenberg Universitaet Mainz 55131 Mainz (Rheinland-Pfalz) GermanyRekrutierend» Google-MapsUniversitaetsmedizin Mannheim 68167 Mannheim (Baden-Württemberg) GermanyRekrutierend» Google-MapsKlinikum der LMU Muenchen 81377 Muenchen (Bayern) GermanyRekrutierend» Google-MapsKlinikum rechts der Isar der TUM 81675 Muenchen (Bayern) GermanyRekrutierend» Google-MapsUniversitaetsklinikum der Eberhard Karls Universitaet Tuebingen 72076 Tuebingen (Baden-Württemberg) GermanyRekrutierend» Google-MapsUniversitaetsklinikum Ulm 89081 Ulm (Baden-Württemberg) GermanyRekrutierend» Google-MapsKlinikum der Stadt Wolfsburg 38440 Wolfsburg (Niedersachsen) GermanyRekrutierend» Google-MapsMayo Clinic - Arizona 85054 Phoenix United StatesRekrutierend» Google-MapsThe Oncology Institute Clinical Research 90703 Cerritos United StatesRekrutierend» Google-MapsCancer and Blood Specialty Clinic 90241 Downey United StatesRekrutierend» Google-MapsCity of Hope National Medical Center 91010 Duarte United StatesRekrutierend» Google-MapsUniversity of California Los Angeles 90095 Los Angeles United StatesRekrutierend» Google-MapsUniversity of California Irvine 92868 Orange United StatesRekrutierend» Google-MapsTorrance Memorial Physician Network 90277 Redondo Beach United StatesRekrutierend» Google-MapsTranslational Research in Oncology - US Inc 90404 Santa Monica United StatesRekrutierend» Google-MapsTranslational Research in Oncology US Inc, Trio Central Pharmacy 90404 Santa Monica United StatesRekrutierend» Google-MapsOlive View-University of California in Los Angeles Medical Center 91342 Sylmar United StatesRekrutierend» Google-MapsPresbyterian Intercommunity Hospital Health Whitter Hospital 90602 Whittier United StatesRekrutierend» Google-MapsYale New Haven Hospital Yale Cancer Center 06520 New Haven United StatesRekrutierend» Google-MapsFlorida Cancer Specialists - Fort Myers 33901 Fort Myers United StatesRekrutierend» Google-MapsMayo Clinic 32224 Jacksonville United StatesRekrutierend» Google-MapsAdventist Health System/Sunbelt, Inc d/b/a AdventHealth Orlando 32804 Orlando United StatesRekrutierend» Google-MapsOrlando Health Cancer Institute 32806 Orlando United StatesRekrutierend» Google-MapsUniversity of Illinois Chicago 60612 Chicago United StatesRekrutierend» Google-MapsGreater Baltimore Medical Center 21204 Baltimore United StatesRekrutierend» Google-MapsHenry Ford Health System 48202 Detroit United StatesRekrutierend» Google-MapsMayo Clinic 55905 Rochester United StatesRekrutierend» Google-MapsSummit Medical Group 07932 Florham Park United StatesRekrutierend» Google-MapsMemorial Sloan Kettering Cancer Center 10022 New York United StatesRekrutierend» Google-MapsStony Brook University Medical Center 11794-7263 Stony Brook United StatesRekrutierend» Google-MapsFirstHealth Cancer Center 28374 Pinehurst United StatesRekrutierend» Google-MapsGabrail Cancer Center, LLC 44718 Canton United StatesRekrutierend» Google-MapsProvidence Portland Medical Center 97213 Portland United StatesRekrutierend» Google-MapsSaint Lukes University Health Network 18104 Allentown United StatesRekrutierend» Google-MapsMedical University of South Carolina 29425 Charleston United StatesRekrutierend» Google-MapsWest Cancer Center 38138 Germantown United StatesRekrutierend» Google-MapsSarah Cannon Research Institute 37203 Nashville United StatesRekrutierend» Google-MapsTexas Oncology - Austin Midtown 78705 Austin United StatesRekrutierend» Google-MapsUniversity of Texas MD Anderson Cancer Center 77030 Houston United StatesRekrutierend» Google-MapsUnited States Oncology Regulatory Affairs Corporate Office 77380 The Woodlands United StatesRekrutierend» Google-MapsUS Oncology Research Investigational Products Center 77380 The Woodlands United StatesRekrutierend» Google-MapsVirginia Oncology Associates 23502 Norfolk United StatesRekrutierend» Google-MapsNorthwest Cancer Specialists - Vancouver 98684 Vancouver United StatesRekrutierend» Google-MapsAurora Health Care Metro Inc 53215 Milwaukee United StatesRekrutierend» Google-MapsCemic C1431FWO Ciudad Autonoma de Buenos Aires ArgentinaRekrutierend» Google-MapsHospital Italiano de La Plata 1900 La Plata ArgentinaRekrutierend» Google-MapsCentro Medico Austral C1019ABS Ciudad Autónoma de Buenos Aires ArgentinaRekrutierend» Google-MapsFundacion Ars Medica 4600 San Salvador de Jujuy ArgentinaRekrutierend» Google-MapsClinica Viedma 8500 Viedma ArgentinaRekrutierend» Google-MapsHospital Provincial del Centenario S2002KDS Rosario ArgentinaRekrutierend» Google-MapsExelsus Oncologia Clinica 4000 San Miguel de Tucuman ArgentinaRekrutierend» Google-MapsFundacion Respirar C1426ABP Buenos Aires ArgentinaRekrutierend» Google-MapsHospital Italiano C1199ABB Capital Federal ArgentinaRekrutierend» Google-MapsSanatorio Allende X5000JHQ Córdoba ArgentinaRekrutierend» Google-MapsHospital Privado Universitario de Cordoba X5016KEH Córdoba ArgentinaRekrutierend» Google-MapsCentro Oncologico Riojano Integral F5300COE La Rioja ArgentinaRekrutierend» Google-MapsGenesisCare -North Shore Oncology 2065 St Leonards AustraliaRekrutierend» Google-MapsCalvary Mater Newcastle Hospital 2298 Waratah AustraliaRekrutierend» Google-MapsThe Queen Elizabeth Hospital 5011 Woodville South AustraliaRekrutierend» Google-MapsBallarat Health Services 3350 Ballarat AustraliaRekrutierend» Google-MapsAustin Health, Austin Hospital 3084 Heidelberg AustraliaRekrutierend» Google-MapsMedizinische Universitaet Graz 8036 Graz AustriaRekrutierend» Google-MapsMedizinische Universitaet Innsbruck 6020 Innsbruck AustriaRekrutierend» Google-MapsLandeskrankenhaus Feldkirch 6830 Rankweil AustriaRekrutierend» Google-MapsLandeskrankenhaus Salzburg 5020 Salzburg AustriaRekrutierend» Google-MapsKrankenhaus Wiener Neustadt 2700 Wiener Neustadt AustriaRekrutierend» Google-MapsUniversitaetsklinikum Allgemeines Krankenhaus Wien 1090 Wien AustriaRekrutierend» Google-MapsInstitut Jules Bordet B-1070 Brussels BelgiumRekrutierend» Google-MapsUniversite Catholique de Louvain Cliniques Universitaires Saint Luc 1200 Bruxelles BelgiumRekrutierend» Google-MapsGrand Hopital de Charleroi 5530 Charleroi BelgiumRekrutierend» Google-MapsUniversitair Ziekenhuis Antwerpen 2650 Edegem BelgiumRekrutierend» Google-MapsUniversitair Ziekenhuis Gent 9000 Gent BelgiumRekrutierend» Google-MapsUniversitair Ziekenhuis Brussel 1090 Jette BelgiumRekrutierend» Google-MapsUniversitair Ziekenhuis Leuven - Campus Gasthuisberg 3000 Leuven BelgiumRekrutierend» Google-MapsHopital De Libramont 6800 Libramont BelgiumRekrutierend» Google-MapsCentre Hospitalier Universitaire de Liege - Sart Tilman 4000 Liege BelgiumRekrutierend» Google-MapsAlgemeen Ziekenhuis Turnhout Campus Sint-Jozef 2300 Turnhout BelgiumRekrutierend» Google-MapsHospital Haroldo Juacaba - Instituto do Cancer do Ceara 60430-230 Fortaleza BrazilRekrutierend» Google-MapsHospital Sirio Libanes 70200-730 Brasilia BrazilRekrutierend» Google-MapsHospital Evangelico de Cachoeiro de Itapemirim 29308-014 Cachoeiro de Itapemirim BrazilRekrutierend» Google-MapsPersonal Oncologia de Precisao e Personalizada 30130-090 Belo Horizonte BrazilRekrutierend» Google-MapsLiga Norte-Riograndense Contra O Cancer 59075-740 Natal BrazilRekrutierend» Google-MapsHospital das Clinicas de Porto Alegre 90035-003 Porto Alegre BrazilRekrutierend» Google-MapsCentro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital Mae de Deus 90110-270 Porto Alegre BrazilRekrutierend» Google-MapsFundacao Pio 12 Hospital de Amor de Barretos 14784-400 Barretos BrazilRekrutierend» Google-MapsInstituto do Cancer Arnaldo Vieira de Carvalho 01221-020 Sao Paulo BrazilRekrutierend» Google-MapsSociedade Beneficente de Senhoras Hospital Sirio Libanes 01308-050 Sao Paulo BrazilRekrutierend» Google-MapsFundacao Antonio Prudente AC Camargo Cancer Center 01508-010 Sao Paulo BrazilRekrutierend» Google-MapsFundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto 15090-000 São José do Rio Preto BrazilRekrutierend» Google-MapsInstituto Coi 22793-080 Rio de Janeiro BrazilRekrutierend» Google-MapsInstituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp 04501-000 São Paulo BrazilRekrutierend» Google-MapsComplex Oncology Center - Burgas 8000 Burgas BulgariaRekrutierend» Google-MapsSpecialized Hospital for Active Treatment of Oncology - Haskovo EOOD 6300 Haskovo BulgariaRekrutierend» Google-MapsMultiprofile Hospital for Active Treatment - Uni Hospital OOD 4500 Panagyurishte BulgariaRekrutierend» Google-MapsMultiprofile Hospital for Active Treatment Central Onco Hospital OOD 4000 Plovdiv BulgariaRekrutierend» Google-MapsMilitary Medical Academy Multiprofile Hospital for Active Treatment - Sofia 1606 Sofia BulgariaRekrutierend» Google-MapsMultiprofile Hospital for Active Treatment Serdika EOOD 1632 Sofia BulgariaRekrutierend» Google-MapsLondon Health Sciences Centre N6A 5W9 London CanadaRekrutierend» Google-MapsPrincess Margaret Cancer Centre M4G 2C1 Toronto CanadaRekrutierend» Google-MapsSunnybrook Research Institute Sunnybrook Health Sciences Centre M4N 3M5 Toronto CanadaRekrutierend» Google-MapsJewish General Hospital H3T 1E2 Montreal CanadaRekrutierend» Google-MapsCentre Hospitalier de L Universite de Montreal H2X 3E4 Montréal CanadaRekrutierend» Google-MapsCHU de Quebec Hopital de l Enfant Jesus G1J 1Z4 Quebec CanadaRekrutierend» Google-MapsCentro De Estudios Clínicos Suecia SpA 7510062 Santiago de Chile ChileRekrutierend» Google-MapsOncocentro Apys 2520598 Viña del Mar ChileRekrutierend» Google-MapsIC La Serena Research 1720430 La Serena ChileRekrutierend» Google-MapsCentro de Estudios Clinicos SAGA Spa 7500653 Santiago ChileRekrutierend» Google-MapsOncovida 7510032 Santiago ChileRekrutierend» Google-MapsIcegclinic 8241479 Santiago ChileRekrutierend» Google-MapsCentro de Estudios Clinicos e Investigaciones Medicas CeCim 8330336 Santiago ChileRekrutierend» Google-MapsThe First Affiliated Hospital of Bengbu Medical University 233099 Bengbu ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Anhui Medical University 230022 Hefei ChinaRekrutierend» Google-MapsAnhui Provincial Cancer Hospital 230031 Hefei ChinaRekrutierend» Google-MapsCancer Hospital of Chinese Academy of Medical Sciences 100021 Beijing ChinaRekrutierend» Google-MapsPeking Union Medical College Hospital, Chinese Academy of Medical Sciences 100032 Beijing ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Chongqing Medical University 400042 Chongqing ChinaRekrutierend» Google-MapsFujian Medical University Union Hospital 350001 Fuzhou ChinaRekrutierend» Google-MapsFujian Cancer Hospital 350014 Fuzhou ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Xiamen University 361003 Xiamen ChinaRekrutierend» Google-MapsLanzhou University Second Hospital 730030 Lanzhou ChinaRekrutierend» Google-MapsGansu Provincial Cancer Hospital 730050 Lanzhou ChinaRekrutierend» Google-MapsGansu Wuwei Tumour Hospital 733000 Wuwei ChinaRekrutierend» Google-MapsThe first people's Hospital of Foshan 528000 Foshan ChinaRekrutierend» Google-MapsSun Yat-sen University Cancer Center 510030 Guangzhou ChinaRekrutierend» Google-MapsGuangdong Provincial Peoples Hospital 510180 Guangzhou ChinaRekrutierend» Google-MapsCancer Hospital of Shantou University Medical College 515031 Shantou ChinaRekrutierend» Google-MapsGuangxi Medical University Cancer Hospital 530021 Nanning ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Hainan Medical University 570102 Haikou ChinaRekrutierend» Google-MapsFourth Hospital of Hebei Medical University 050011 Shijiazhuang ChinaRekrutierend» Google-MapsHarbin Medical University Cancer Hospital 150000 Harbin ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Henan University of science and Technology 471000 Luoyang ChinaRekrutierend» Google-MapsHenan Cancer Hospital 450000 Zhengzhou ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Zhengzhou University 450052 Zhengzhou ChinaRekrutierend» Google-MapsTaihe Hospital Affiliated Hospital of Hubei University of Medicine 442000 Shiyan ChinaRekrutierend» Google-MapsThe Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Tech 430000 Wuhan ChinaRekrutierend» Google-MapsTongji Hospital Tongji Medical College Of Hust 430030 Wuhan ChinaRekrutierend» Google-MapsHubei Cancer Hospital 430079 Wuhan ChinaRekrutierend» Google-MapsThe Second Xiangya Hospital of Central South Universiy 410000 Changsha ChinaRekrutierend» Google-MapsXiangya Hospital of Central South University 410000 Changsha ChinaRekrutierend» Google-MapsHunan Cancer Hospital 410013 Changsha ChinaRekrutierend» Google-MapsInner Mongolia Autonomous Region Peoples Hospital 010017 Hohhot ChinaRekrutierend» Google-MapsThe First People's Hospital of Changzhou 213003 Changzhou ChinaRekrutierend» Google-MapsNanjing Drum Tower Hospital 210008 Nanjing ChinaRekrutierend» Google-MapsZhongda Hospital Southeast University 210009 Nanjing ChinaRekrutierend» Google-MapsThe Second Affiliated Hospital of Soochow University 215004 Suzhou ChinaRekrutierend» Google-MapsAffiliated Hospital of Jiangnan University 214122 Wuxi ChinaRekrutierend» Google-MapsThe Affiliated Hospital of Xuzhou Medical University 221002 Xuzhou ChinaRekrutierend» Google-MapsAffiliated Hospital of Yangzhou University 225001 Yangzhou ChinaRekrutierend» Google-MapsNorthern Jiangsu Peoples Hospital 225001 Yangzhou ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Nanchang University 330006 Nanchang ChinaRekrutierend» Google-MapsChina-Japan Union Hospital of Jilin University 130022 Changchun ChinaRekrutierend» Google-MapsGeneral Hospital of Ningxia Medical University 750004 Yinchuan ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Xian Jiaotong University 710061 Xian ChinaRekrutierend» Google-MapsShaanxi Provincial Peoples Hospital 710068 Xian ChinaRekrutierend» Google-MapsQilu Hospital of Shandong University 250011 Jinan ChinaRekrutierend» Google-MapsThe Affiliated Cancer Hospital of Shandong First Medical University 250117 Jinan ChinaRekrutierend» Google-MapsAffiliated Hospital of Jining Medical University 272007 Jining ChinaRekrutierend» Google-MapsThe Affiliated Hospital of Qingdao University 266000 Qingdao ChinaRekrutierend» Google-MapsRuijin Hospital Shanghai Jiao Tong University School of Medicine 200025 Shanghai ChinaRekrutierend» Google-MapsFudan University Shanghai Cancer Center 200032 Shanghai ChinaRekrutierend» Google-MapsZhongshan Hospital Fudan University 200032 Shanghai ChinaRekrutierend» Google-MapsShanghai East Hospital 200123 Shanghai ChinaRekrutierend» Google-MapsChangzhi Peoples Hospital 046000 Changzhi ChinaRekrutierend» Google-MapsLinfen Central Hospital 100032 Linfen ChinaRekrutierend» Google-MapsSichuan Cancer Hospital 610041 Chengdu ChinaRekrutierend» Google-MapsWest China Hospital of Sichuan University 610041 Chengdu ChinaRekrutierend» Google-MapsThe Affiliated Hospital of Southwest Medical University 646000 Luzhou ChinaRekrutierend» Google-MapsTianjin Medical University Cancer institute and hospital 300060 Tianjin ChinaRekrutierend» Google-MapsYunnan Cancer Hospital 650106 Kunming ChinaRekrutierend» Google-MapsThe First Affiliated Hospital Zhejiang University School of Medicine 310009 Hangzhou ChinaRekrutierend» Google-MapsThe Second Affiliated Hospital Zhejiang University School of Medicine 310009 Hangzhou ChinaRekrutierend» Google-MapsSir Run Run Shaw Hospital Zhejiang University School of Medicine 310016 Hangzhou ChinaRekrutierend» Google-MapsZhejiang Cancer Hospital 310022 Hangzhou ChinaRekrutierend» Google-MapsTaizhou Hospital of Zhejiang Province 317000 Linhai ChinaRekrutierend» Google-MapsLishui Municipal central Hospital 323000 Lishui ChinaRekrutierend» Google-MapsThe First Affiliate Hospital of Ningbo University 315010 Ningbo ChinaRekrutierend» Google-MapsHospital Pablo Tobon Uribe 050034 Medellin ColombiaRekrutierend» Google-MapsInstitucion Prestadora de Servicios de Salud Sociedad Médica Rionegro SA Somer SA 054040 Rionegro ColombiaRekrutierend» Google-MapsSociedad de Oncologia y Hematologia del Cesar 200001 Valledupar ColombiaRekrutierend» Google-MapsFundacion Cardiovascular de Colombia 681017 Bucaramanga ColombiaRekrutierend» Google-MapsFundacion Oftalmologica de Santander - Foscal 681004 Floridablanca ColombiaRekrutierend» Google-MapsFakultni nemocnice Hradec Kralove 500 05 Hradec Kralove CzechiaRekrutierend» Google-MapsFakultni nemocnice Olomouc 779 00 Olomouc CzechiaRekrutierend» Google-MapsFakultni nemocnice Kralovske Vinohrady 100 34 Praha 10 CzechiaRekrutierend» Google-MapsVseobecna fakultni nemocnice v Praze 128 08 Praha 2 CzechiaRekrutierend» Google-MapsFakultni Thomayerova nemocnice 140 59 Praha 4 CzechiaRekrutierend» Google-MapsCentre Hospitalier Universitaire Amiens Picardie - Hopital Sud 80054 Amiens Cedex 1 FranceRekrutierend» Google-MapsCentre Hospitalier Regional Universitaire de Besancon, Hopital Jean Minjoz 25030 Besançon FranceRekrutierend» Google-MapsInstitut Bergonie 33000 Bordeaux FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire de Brest - Cavale Blanche 29609 Brest Cedex FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire de Clermont Ferrand, Hopital Estaing 63003 Clermont-Ferrand cedex 1 FranceRekrutierend» Google-MapsCentre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez 59037 Lille FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire de Limoges - Hopital Dupuytren 87042 Limoges Cedex FranceRekrutierend» Google-MapsCentre Leon Berard 69373 Lyon cedex 8 FranceRekrutierend» Google-MapsCentre Antoine Lacassagne 06189 Nice FranceRekrutierend» Google-MapsHôpital Saint Louis 75475 Paris Cedex 10 FranceRekrutierend» Google-MapsInstitut Mutualiste Montsouris 75674 Paris Cedex 14 FranceRekrutierend» Google-MapsHopital Europeen Georges Pompidou 75015 Paris FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire de Rennes - Hopital Pontchaillou 35033 Rennes Cedex 9 FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire de Rouen 76031 Rouen Cedex FranceAbgebrochen» Google-MapsCentre Rene Gauducheau - Institut de Cancerologie de l Ouest 44800 Saint Herblain FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire Nord de Saint Etienne - Hopital Nord 42270 Saint Priest en Jarez FranceRekrutierend» Google-MapsInstitut de cancerologie Strasbourg Europe 67065 Strasbourg cedex FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire de Toulouse - Hopital Rangueil 31059 Toulouse Cedex 9 FranceRekrutierend» Google-MapsInstitut Gustave Roussy 94805 Villejuif FranceRekrutierend» Google-MapsPrince of Wales Hospital Shatin, New Territories Hong KongRekrutierend» Google-MapsSemmelweis Egyetem 1082 Budapest HungaryRekrutierend» Google-MapsDel-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet 1097 Budapest HungaryRekrutierend» Google-MapsOrszagos Onkologiai Intezet 1122 Budapest HungaryRekrutierend» Google-MapsDebreceni Egyetem Klinikai Kozpont 4032 Debrecen HungaryRekrutierend» Google-MapsSzabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz 4400 Nyiregyhaza HungaryRekrutierend» Google-MapsTolna Varmegyei Balassa Janos Korhaz 7100 Szekszard HungaryRekrutierend» Google-MapsJasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet 5000 Szolnok HungaryRekrutierend» Google-MapsKomarom-Esztergom Varmegyei Szent Borbala Korhaz 2800 Tatabanya HungaryRekrutierend» Google-MapsRambam Health Care Campus 3109601 Haifa IsraelRekrutierend» Google-MapsShaare Zedek Medical Center 9103102 Jerusalem IsraelRekrutierend» Google-MapsHadassah Ein-Kerem Medical Center 9112001 Jerusalem IsraelRekrutierend» Google-MapsSheba Medical Center 5262000 Ramat Gan IsraelRekrutierend» Google-MapsTel-Aviv Sourasky Medical Center 6423906 Tel Aviv IsraelRekrutierend» Google-MapsAzienda Ospedaliero Universitaria Ospedali Riuniti di Ancona 60126 Ancona ItalyRekrutierend» Google-MapsAzienda Socio Sanitaria Territoriale Papa Giovanni xxiii 24127 Bergamo ItalyRekrutierend» Google-MapsIstituto Ospedaliero Fondazione Poliambulanza 25124 Brescia ItalyRekrutierend» Google-MapsEnte Ospedaliero IRCCS Saverio De Bellis 70013 Castellana Grotte ItalyRekrutierend» Google-MapsAzienda Socio Sanitaria Territoriale di Cremona 26100 Cremona ItalyRekrutierend» Google-MapsAzienda Ospedaliero Universitaria Careggi 50134 Firenze ItalyRekrutierend» Google-MapsOspedale Policlinico San Martino IRCCS 16132 Genova ItalyRekrutierend» Google-MapsIRCCS Ospedale San Raffaele 20132 Milano ItalyRekrutierend» Google-MapsFondazione IRCCS Istituto Nazionale dei Tumori 20133 Milano ItalyRekrutierend» Google-MapsAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda 20162 Milano ItalyRekrutierend» Google-MapsAzienda Ospedaliero Universitaria Luigi Vanvitelli 80131 Napoli ItalyRekrutierend» Google-MapsIstituto Oncologico Veneto IRCCS 35128 Padova ItalyRekrutierend» Google-MapsAzienda Ospedaliera Universitaria Pisana 56126 Pisa ItalyRekrutierend» Google-MapsNagoya University Hospital 466-8560 Nagoya-shi JapanRekrutierend» Google-MapsChiba Cancer Center 260-8717 Chiba-shi JapanRekrutierend» Google-MapsNational Cancer Center Hospital East 277-8577 Kashiwa-shi JapanRekrutierend» Google-MapsNational Hospital Organization Shikoku Cancer Center 791-0280 Matsuyama-shi JapanRekrutierend» Google-MapsNational Hospital Organization Kyushu Cancer Center 811-1395 Fukuoka-shi JapanRekrutierend» Google-MapsGifu University Hospital 501-1194 Gifu-shi JapanRekrutierend» Google-MapsHokkaido University Hospital 060-8648 Sapporo JapanRekrutierend» Google-MapsHyogo Cancer Center 673-8558 Akashi-shi JapanRekrutierend» Google-MapsKobe City Medical Center General Hospital 650-0047 Kobe-shi JapanRekrutierend» Google-MapsYokohama City University Medical Center 232-0024 Yokohama-shi JapanRekrutierend» Google-MapsKanagawa Prefectural Hospital Organization Kanagawa Cancer Center 241-8515 Yokohama-shi JapanRekrutierend» Google-MapsNiigata Cancer Center Hospital 951-8566 Niigata-shi JapanRekrutierend» Google-MapsKansai Medical University Hospital 573-1191 Hirakata-shi JapanRekrutierend» Google-MapsOsaka International Cancer Institute 541-8567 Osaka-shi JapanRekrutierend» Google-MapsKindai University Hospital 589-8511 Osakasayama-shi JapanRekrutierend» Google-MapsOsaka University Hospital 565-0871 Suita-shi JapanRekrutierend» Google-MapsSaitama Cancer Center 362-0806 Kitaadachi-gun JapanRekrutierend» Google-MapsShizuoka Cancer Center 411-8777 Sunto-gun JapanRekrutierend» Google-MapsNational Cancer Center Hospital 104-0045 Chuo-ku JapanRekrutierend» Google-MapsThe Cancer Institute Hospital of Japanese Foundation for Cancer Research 135-8550 Koto-ku JapanRekrutierend» Google-MapsKyungpook National University Chilgok Hospital 41404 Daegu Korea, Republic ofRekrutierend» Google-MapsChungnam National University Hospital 35015 Daejeon Korea, Republic ofRekrutierend» Google-MapsNational Cancer Center 10408 Goyang-si Gyeonggi-do Korea, Republic ofRekrutierend» Google-MapsJeonbuk National University Hospital 54907 Jeonju-si, Jeollabuk-do Korea, Republic ofRekrutierend» Google-MapsSeoul National University Bundang Hospital 13620 Seongnam-si, Gyeonggi-do Korea, Republic ofRekrutierend» Google-MapsKorea University Anam Hospital 02841 Seoul Korea, Republic ofRekrutierend» Google-MapsSeoul National University Hospital 03080 Seoul Korea, Republic ofRekrutierend» Google-MapsKangbuk Samsung Hospital 03181 Seoul Korea, Republic ofRekrutierend» Google-MapsSeverance Hospital Yonsei University Health System 03722 Seoul Korea, Republic ofRekrutierend» Google-MapsAsan Medical Center 05505 Seoul Korea, Republic ofRekrutierend» Google-MapsSamsung Medical Center 06351 Seoul Korea, Republic ofRekrutierend» Google-MapsThe Catholic University of Korea Seoul St Marys Hospital 06591 Seoul Korea, Republic ofRekrutierend» Google-MapsKorea University Guro Hospital 08308 Seoul Korea, Republic ofRekrutierend» Google-MapsBeskidzkie Centrum Onkologii Szpital Miejski imienia Jana Pawla Drugiego 43-300 Bielsko-Biala PolandRekrutierend» Google-MapsNarodowy Instytut Onkologii im M Sklodowskiej-Curie Panstwowy Instytut Badawczy Oddzial w Gliwicach 44-102 Gliwice PolandRekrutierend» Google-MapsPrzychodnia Lekarska Komed Roman Karaszewski 62-500 Konin PolandRekrutierend» Google-MapsSamodzielny Publiczny Szpital Kliniczny Nr 1 20-080 Lublin PolandRekrutierend» Google-MapsSzpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji 10-228 Olsztyn PolandRekrutierend» Google-MapsMazowiecki Szpital Wojewodzki im Sw Jana Pawla II w Siedlcach spzoo 08-110 Siedlce PolandRekrutierend» Google-MapsCentrum Medyczne Pratia Poznan 60-185 Skorzewo PolandRekrutierend» Google-MapsUniwersytecki Szpital Kliniczny nr 1 im prof Tadeusza Sokolowskiego Pum w Szczecinie 71-252 Szczecin PolandRekrutierend» Google-MapsLux med onkologia sp zoo szpital szamocka 01-748 Warszawa PolandRekrutierend» Google-MapsNarodowy Instytut Onkologii im Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy 02-034 Warszawa PolandRekrutierend» Google-MapsMtz Clinical Research powered by Pratia 02-172 Warszawa PolandRekrutierend» Google-MapsUniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego we Wroclawiu 50-556 Wroclaw PolandAbgebrochen» Google-MapsUnidade Local de 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1. Part 1: Number of Participants Who Experienced DLTs (Time Frame - 28 days)
2. Part 1: Number of Participants Who Experienced One or More Treatment-Emergent Adverse Events (TEAEs) (Time Frame - Up to 4.5 years)
3. Part 1: Number of Participants Who Experienced One or More Related TEAEs (Time Frame - Up to 4.5 years)
4. Part 1: Number of Participants With Clinically Significant Changes in Vital Signs (Time Frame - Up to 4.5 years)
5. Part 1: Number of Participants With Clinically Significant Changes in Visual Acuity (Time Frame - Up to 4.5 years)
6. Part 1: Number of Participants With Clinically Significant Changes in Physical Examinations (Time Frame - Up to 4.5 years)
7. Part 1: Number of Participants with Clinically Significant Changes in Clinical Laboratory Tests (Time Frame - Up to 4.5 years)
8. Part 2: Overall Survival in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Up to 4.5 years)
Secondary outcome:
1. Part 1: Objective Response (OR) (Time Frame - Up to 4.5 years)
2. Part 1: Duration of Response (DoR) (Time Frame - Up to 4.5 years)
3. Part 1: Disease Control Rate (DCR) (Time Frame - Up to 4.5 years)
4. Part 1: Progression Free Survival (PFS) (Time Frame - Up to 4.5 years)
5. Part 1: Overall Survival (Time Frame - Up to 4.5 years)
6. Part 1: Maximum Observed Concentration (Cmax) of Bemarituzumab (Time Frame - Day 1 to up to 4.5 years)
7. Part 1: Area Under the Concentration Time Curve (AUC) of Bemarituzumab (Time Frame - Day 1 to up to 4.5 years)
8. Part 1: Observed Concentration at the End of a Dose Interval (Ctrough) of Bemarituzumab (Time Frame - Day 1 to up to 4.5 years)
9. Part 1: Number of Participants With Anti-Bemarituzumab Antibody Formation (Time Frame - Day 1 to up to 4.5 years)
10. Part 2: PFS in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Up to 4.5 years)
11. Part 2: OR in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Up to 4.5 years)
12. Part 2: Number of Participants Who Experienced One or More TEAEs (Time Frame - Up to 4.5 years)
13. Part 2: Number of Participants With Clinically Significant Changes in Vital Signs (Time Frame - Up to 4.5 years)
14. Part 2: Number of Participants With Clinically Significant Changes in Visual Acuity (Time Frame - Up to 4.5 years)
15. Part 2: Number of Participants with Clinically Significant Changes in Clinical Laboratory Tests (Time Frame - Up to 4.5 years)
16. Part 2: Overall Survival in All Randomized Participants (Time Frame - Up to 4.5 years)
17. Part 2: PFS in All Randomized Participants (Time Frame - Up to 4.5 years)
18. Part 2: Objective Response Rate (ORR) in All Randomized Participants (Time Frame - Up to 4.5 years)
19. Part 2: DoR in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Up to 4.5 years)
20. Part 2: DCR in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Up to 4.5 years)
21. Part 2: Mean Score in European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Version 3.0 (QLQ-C30) Individual Scores in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Up to 4.5 years)
22. Part 2: Change From Baseline in EORTC QLQ-C30 Individual Scores in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Baseline to up to 4.5 years)
23. Part 2: Mean Score in Stomach Cancer Related Symptoms Measured by EORTC Quality of Life Questionnaire-Stomach 22 (QLQ-STO22) in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Up to 4.5 years)
24. Part 2: Change From Baseline in Stomach Cancer Related Symptoms Measured by EORTC QLQ-STO22 in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Baseline to up to 4.5 years)
25. Part 2: Mean Score of Visual Analogue Scale (VAS) Scores as Measured by EuroQol 5-dimensional (EQ-5D-5L) in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Up to 4.5 years)
26. Part 2: Change From Baseline of VAS Scores as Measured by EQ-5D-5L in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Baseline to up to 4.5 years)
27. Part 2: Time to Deterioration in Stomach Cancer Related Symptoms Measured by EORTC QLQ-STO22 in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Day 1 to up to 4.5 years)
28. Part 2: Time to Deterioration in Health-Related Quality of Life (HRQoL) Scores in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Day 1 to up to 4.5 years)
29. Part 2: Time to Deterioration in Physical Function Scores in FGFR2b ≥ 10% 2+/3+ Tumor Cell Staining Participants (Time Frame - Day 1 to up to 4.5 years)
30. Part 2: Cmax of Bemarituzumab (Time Frame - Day 1 to up to 4.5 years)
31. Part 2: Ctrough of Bemarituzumab (Time Frame - Day 1 to up to 4.5 years)
32. Part 2: Number of Participants With Anti-Bemarituzumab Antibody Formation (Time Frame - Day 1 to up to 4.5 years)
Experimental: Part 1 Safety Lead-in: Bemarituzumab with mFOLFOX6 and Nivolumab Participants will be administered bemarituzumab at different doses with mFOLFOX6 and
nivolumab to determine the recommended phase 3 dose (RP3D) based on occurrence of
dose-limiting toxicities (DLTs), and on an evaluation of the overall safety,
tolerability, and pharmacokinetics (PK).
Experimental: Part 2: Bemarituzumab with chemotherapy (mFOLFOX6 or CAPOX) and Nivolumab Participants will be administered bemarituzumab at the RP3D determined from Part 1 in
combination with mFOLFOX6 and nivolumab on a 14-day cycle.
Or participants will be administered bemarituzumab in combination with CAPOX and
nivolumab on a 21-day cycle.
Placebo Comparator: Part 2: Placebo with chemotherapy (mFOLFOX6 or CAPOX) and Nivolumab Participants will be administered placebo comparator in combination with mFOLFOX6 and
nivolumab on a 14-day cycle.
Or participants will be administered placebo comparator in combination with CAPOX and
nivolumab on a 21-day cycle.
Bemarituzumab (AMG 552): Bemarituzumab will be administered as intravenous (IV) infusion.
Nivolumab: Nivolumab will be administered as IV infusion.
Chemotherapy: mFOLFOX6: 5-fluorouracil, leucovorin, and oxaliplatin will be administered as IV
infusion.
OR CAPOX: oxaliplatin will be administered as IV infusion and capecitabine will be
administered orally.
Placebo: Placebo will be administered as IV infusion.
Quelle: ClinicalTrials.gov
Sie können folgenden Inhalt einem Kollegen empfehlen:
"Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer."
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